RESUMO
The composition of the essential oils (EOs) of O. vulgare L. EO and T. vulgaris EO, were analyzed by GC and GC-MS. Antifungal activities of the EOs and its main component, carvacrol, were evaluated against 27 clinical isolates of Malassezia furfur. Minimum inhibitory concentrations (MICs) were measured according to the broth microdilution protocols by Clinical and Laboratory Standards Institute (CLSI) modified for Malassezia spp. EOs and carvacrol showed low MIC values ranged 450-900 µg/ml against M. furfur. No differences in EOs antifungal activity were observed in sensitive to resistant fluconazole isolates. The antifungal activity obtained showed O. vulgare EO, T. vulgaris EO and carvacrol, their compound, as potential antimicrobial agents against M. furfur, yeast associated with human mycoses.
Assuntos
Antifúngicos/isolamento & purificação , Cimenos/isolamento & purificação , Malassezia/efeitos dos fármacos , Óleos Voláteis/isolamento & purificação , Origanum/toxicidade , Thymus (Planta)/toxicidade , Anti-Infecciosos/farmacologia , Antifúngicos/farmacologia , Cimenos/farmacologia , Fluconazol/farmacologia , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Testes de Sensibilidade Microbiana , Óleos Voláteis/química , Óleos Voláteis/farmacologia , Origanum/química , Thymus (Planta)/química , Leveduras/efeitos dos fármacosRESUMO
Cuminum cyminum fruits and T. vulgaris leaves were fed to male Wistar rats at 2% or 10% of standard diet for 6 w. A mixture (5% +5%) of the 2 plants was also fed to rats for a similar period. Diets containing 2% C. cyminum fruits, 2% or 10% T. vulgaris leaves were not toxic to rats. Impairment of growth and enterohepatonephropathy were observed in the rats fed a diet containing 10% C. cyminum fruits. These changes were also seen in the rats fed the mixture of the 2 plants and were accompanied by leukopenia, anemia and increases in serum AST activity and urea and by decreased total protein and albumin levels.
