Assuntos
Transplante de Células-Tronco Hematopoéticas/história , Transplante de Células-Tronco de Sangue Periférico/história , Condicionamento Pré-Transplante/história , Transplante de Medula Óssea/história , Transplante de Medula Óssea/métodos , Antígenos HLA/imunologia , Transplante de Células-Tronco Hematopoéticas/métodos , História do Século XX , História do Século XXI , Hospitais Gerais , Humanos , Transplante de Células-Tronco de Sangue Periférico/métodos , Singapura , Condicionamento Pré-Transplante/métodosRESUMO
In the 1950s, the first infusions of hematopoietic stem cells were given as a form of treatment for childhood leukemia. This heralded the beginning of a field that has expanded to include the treatment of immune deficiencies, a variety of leukemias and solid tumors, and then genetic diseases. A number of milestones are highlighted, particularly in regard to the use of alternative sources of hematopoietic stem cells such as unrelated donors, peripheral blood stem cells and umbilical cord stem cells. In addition, newer techniques of using non-myeloablative preparative regimens helped to reduce the toxicity and long-term consequences of hematopoietic stem cell transplant. Many diseases now benefit from the replacement of the marrow stem cells and the provision of a new immune system and improved immune surveillance.
