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1.
J Neurol ; 271(4): 1802-1812, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38055022

RESUMO

OBJECTIVES: This study aimed to determine the usefulness of electrophysiological exercise tests. The significance of slightly abnormal exercise tests was also examined. METHODS: We identified all the patients who had undergone exercise testing between February 2007 to June 2022 in Tampere University Hospital, Finland. Their medical records after diagnostic workup and exercise test reports were reviewed. A binary logistic regression was performed to evaluate the association between positive test result in short exercise test, long exercise test, or short exercise test with cooling and genetically confirmed skeletal muscle channelopathy or myotonic disorder. RESULTS: We identified 256 patients. 27 patients were diagnosed with nondystrophic myotonia, periodic paralysis, myotonic dystrophy type 1, myotonic dystrophy type 2, or other specified myopathy. 14 patients were suspected to have a skeletal muscle channelopathy, but pathogenic variants could not be identified. The remaining 215 patients were diagnosed with other conditions than skeletal muscle channelopathy or myotonic disorder. The combined sensitivity of exercise tests was 59.3% and specificity 99.1%. Abnormal exercise test result was associated with increased risk of skeletal muscle channelopathy or myotonic disorder (OR 164.3, 95% CI 28.3-954.6, p < 0.001). CONCLUSIONS: Electrophysiological exercise test is not optimal to exclude skeletal muscle channelopathy. It may be useful if a skeletal muscle channelopathy is suspected and genetic testing is negative or indeterminate and further evidence is required. Slightly abnormal exercise test results are possible in various conditions and result from different aetiologies. There is a demand for neurophysiological studies with higher sensitivity to detect skeletal muscle channelopathies.


Assuntos
Canalopatias , Transtornos Miotônicos , Distrofia Miotônica , Humanos , Teste de Esforço , Estudos Retrospectivos , Canalopatias/diagnóstico , Canalopatias/genética , Músculo Esquelético , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética
2.
Handb Clin Neurol ; 195: 521-532, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37562884

RESUMO

Muscle channelopathies encompass a wide range of mainly episodic conditions that are characterized by muscle stiffness and weakness. The myotonic conditions, characterized predominantly by stiffness, include myotonia congenita, paramyotonia congenita, and sodium channel myotonia. The periodic paralysis conditions include hypokalemic periodic paralysis, hyperkalemic periodic paralysis, and Andersen-Tawil syndrome. Clinical history is key, and diagnosis is confirmed by next-generation genetic sequencing of a panel of known genes but can also be supplemented by neurophysiology studies and MRI. As genetic testing expands, so have the spectrum of phenotypes seen including pediatric presentations and congenital myopathies. Management of these conditions requires a multidisciplinary approach with extra support needed when patients require anesthetics or when pregnant. Patients with Andersen-Tawil syndrome will also need cardiac input. Diagnosis is important as symptomatic treatment is available for all of these conditions but need to be tailored to the gene and variant of the patient.


Assuntos
Síndrome de Andersen , Canalopatias , Transtornos Miotônicos , Paralisia Periódica Hiperpotassêmica , Humanos , Síndrome de Andersen/genética , Canalopatias/genética , Paralisia Periódica Hiperpotassêmica/genética , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Músculo Esquelético , Paralisia , Mutação
3.
Pract Neurol ; 23(1): 74-77, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36192135

RESUMO

A 21-year-old woman developed an acute myotonic reaction while undergoing anaesthesia using succinylcholine. Examination later showed she had shoulder, neck and calf hypertrophy, bilateral symmetrical ptosis and eyelid, handgrip and percussion myotonia. Peripheral neurophysiology studies identified significant, continuous myotonic discharges in both upper and lower limbs. Genetic analysis identified a c.3917G>A (p.Gly1306Glu) mutation in the SCN4A gene, confirming a diagnosis of sodium channel myotonia. Succinylcholine and other depolarising agents can precipitate life-threatening acute myotonic reactions when given to patients with myotonia. Patients with neuromuscular disorders are at an increased risk of perioperative anaesthetic complications. We report a woman who developed an acute myotonic reaction whilst undergoing anaesthesia, in the context of an unrecognised myotonic disorder. We then discuss an approach to the diagnosis of myotonic disorders.


Assuntos
Anestesia , Miotonia , Transtornos Miotônicos , Feminino , Humanos , Adulto Jovem , Adulto , Succinilcolina/efeitos adversos , Força da Mão , Transtornos Miotônicos/induzido quimicamente , Transtornos Miotônicos/diagnóstico , Miotonia/induzido quimicamente , Miotonia/genética , Canal de Sódio Disparado por Voltagem NAV1.4/genética
4.
Continuum (Minneap Minn) ; 28(6): 1778-1799, 2022 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-36537980

RESUMO

PURPOSE OF REVIEW: This article describes the clinical features, diagnosis, pathophysiology, and management of nondystrophic myotonia and periodic paralysis. RECENT FINDINGS: An increasing awareness exists about the genotype-phenotype overlap in skeletal muscle channelopathies, and thus genetic testing is needed to make a definitive diagnosis. Electrodiagnostic testing in channelopathies is highly specialized with significant overlap in various mutation subtypes. Randomized clinical trials have now been conducted in these disorders with expanded treatment options for patients with muscle channelopathies. SUMMARY: Skeletal muscle channelopathies are rare heterogeneous conditions characterized by lifelong symptoms that require a comprehensive management plan that includes pharmacologic and nonpharmacologic interventions. The significant variability in biophysical features of various mutations, coupled with the difficulties of performing clinical trials in rare diseases, makes it challenging to design and implement treatment trials for muscle channelopathies.


Assuntos
Canalopatias , Miotonia , Transtornos Miotônicos , Paralisias Periódicas Familiares , Humanos , Canalopatias/diagnóstico , Canalopatias/genética , Canalopatias/terapia , Músculo Esquelético , Miotonia/diagnóstico , Miotonia/genética , Miotonia/terapia , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Mutação/genética
5.
Muscle Nerve ; 64(1): 95-99, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33835497

RESUMO

INTRODUCTION/AIMS: Paramyotonia congenita (PMC) is a skeletal muscle sodium channelopathy characterized by paradoxical myotonia, cold sensitivity, and exercise/cold-induced paralysis. Treatment with sodium-channel-blocking antiarrhythmic agents may expose patients to a risk of arrhythmia or may be poorly tolerated or ineffective. In this study we explored the effectiveness of non-antiarrhythmic sodium-channel blockers in two patients with PMC. METHODS: Earlier treatment with mexiletine was discontinued for gastrointestinal side effects in one of the patients and lack of clinical benefit in the other. One patient received lacosamide, ranolazine, and buprenorphine, and the other was given buprenorphine only. Drug efficacy was assessed by clinical scores, timed tests, and by long and short exercise tests. RESULTS: In both patients, buprenorphine improved pain scores by at least 50%, stiffness and weakness levels, and handgrip/eyelid-opening times. The fall in compound muscle action potential (CMAP) during short exercise normalized in both patients at baseline, and improved after cooling. During long exercise, one patient showed an earlier recovery of CMAP, and the other patient had a less severe decrease (<60%). With buprenorphine, the fall in CMAP induced by cooling normalized in one patient (from -72% to -4%) and improved (from -49% to -37%) in the other patient. DISCUSSION: Buprenorphine showed promising results for the treatment of exercise-induced paralysis and cold intolerance in the two patients assessed. The exercise test may be useful for quantitative assessment of treatment response. Further studies on a larger number of patients, under carefully controlled conditions, should be considered to address the effectiveness and long-term tolerability of this therapeutic option.


Assuntos
Analgésicos Opioides/uso terapêutico , Buprenorfina/uso terapêutico , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/tratamento farmacológico , Analgésicos Opioides/farmacologia , Buprenorfina/farmacologia , Teste de Esforço/efeitos dos fármacos , Teste de Esforço/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Miotônicos/genética , Canal de Sódio Disparado por Voltagem NAV1.4/genética , Resultado do Tratamento
6.
Artigo em Inglês | MEDLINE | ID: mdl-31536013

RESUMO

To identify similar diseases has significant implications for revealing the etiology and pathogenesis of diseases and further research in the domain of biomedicine. Currently, most methods for the measurement of disease similarity utilize either associations of ontological disease concepts or functional interactions between disease-related genes. These methods are heavily dependent on the ontology, which are not always available, and the selection of datasets. Moreover, many methods suffer from a drawback that they only use a single metric to evaluate disease similarity from an individual data source, which may result in biased conclusions without consideration of other aspects. In this study, we proposed a novel ontology-independent framework, namely RADAR, for learning representations for diseases to deduce their similarities from an integrative perspective. By leveraging the associations between diseases and disease-related biomedical entities, a disease similarity network was built under various metrics. Then, a multi-layer disease similarity network was constructed by integrating multiple disease similarity networks derived from multiple data sources, where the representation learning was derived to provide a comprehensive evaluation of disease similarities. The performance of RADAR was assessed by a benchmark disease set and 100 random disease sets. Experimental results demonstrated that RADAR can detect similar diseases effectively.


Assuntos
Ontologias Biológicas , Biologia Computacional/métodos , Diagnóstico por Computador/métodos , Aprendizado de Máquina , Algoritmos , Humanos , Modelos Biológicos , Transtornos Miotônicos/classificação , Transtornos Miotônicos/diagnóstico
7.
Neurol Clin ; 38(3): 481-491, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32703462

RESUMO

Skeletal muscle channelopathies are rare genetic neuromuscular conditions that include the nondystrophic myotonias and periodic paralyses. They cause disabling muscle symptoms and can limit educational potential, work opportunities, socialization, and quality of life. Effective therapy is available, making it essential to recognize and treat this group of disorders. Here, the authors highlight important aspects regarding diagnosis and management using illustrative case reports.


Assuntos
Síndrome de Andersen/diagnóstico , Síndrome de Andersen/genética , Canalopatias/diagnóstico , Canalopatias/genética , Paralisia Periódica Hipopotassêmica/diagnóstico , Paralisia Periódica Hipopotassêmica/genética , Adolescente , Síndrome de Andersen/fisiopatologia , Canalopatias/fisiopatologia , Humanos , Paralisia Periódica Hipopotassêmica/fisiopatologia , Masculino , Músculo Esquelético/fisiopatologia , Mutação/genética , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Transtornos Miotônicos/fisiopatologia , Doenças da Junção Neuromuscular/diagnóstico , Doenças da Junção Neuromuscular/genética , Doenças da Junção Neuromuscular/fisiopatologia
10.
Muscle Nerve ; 61(6): 808-814, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32129495

RESUMO

INTRODUCTION: Mutations of the voltage-gated sodium channel gene (SCN4A), which encodes Nav1.4, cause nondystrophic myotonia that occasionally is associated with severe apnea and laryngospasm. There are case reports of nondystrophic myotonia due to mutations in the C-terminal tail (CTerm) of Nav1.4, but the functional analysis is scarce. METHODS: We present two families with nondystrophic myotonia harboring a novel heterozygous mutation (E1702del) and a known heterozygous mutation (E1702K). RESULTS: The proband with E1702K exhibited repeated rhabdomyolysis, and the daughter showed laryngospasm and cyanosis. Functional analysis of the two mutations as well as another known heterozygous mutation (T1700_E1703del), all located on EF hand-like motif in CTerm, was conducted with whole-cell recording of heterologously expressed channel. All mutations displayed impaired fast inactivation. DISCUSSION: The CTerm of Nav1.4 is vital for regulating fast inactivation. The study highlights the importance of accumulating pathological mutations of Nav1.4 and their functional analysis data.


Assuntos
Motivos EF Hand/genética , Potenciais da Membrana/fisiologia , Mutação/genética , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Canal de Sódio Disparado por Voltagem NAV1.4/genética , Pré-Escolar , Feminino , Células HEK293 , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Miotônicos/fisiopatologia , Adulto Jovem
11.
Int J Pediatr Otorhinolaryngol ; 125: 199-200, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31382107

RESUMO

We present a unique case of intermittent paradoxical vocal fold motion (PVFM) as the presenting symptom of a rare underlying neuromuscular disorder in a neonate. Paramyotonia congenita (PC) is an autosomal dominant condition that typically presents in infancy with myotonic episodes affecting the skeletal muscles. Our patient developed intermittent episodes of stridor quickly progressing to apnea shortly after birth that were marked by PVFM on laryngoscopy, ultimately leading to the diagnosis of a previously unrecognized mutation in SCN4A, the gene responsible for PC.


Assuntos
Transtornos Miotônicos/diagnóstico , Disfunção da Prega Vocal/diagnóstico , Apneia/etiologia , Feminino , Humanos , Recém-Nascido , Laringoscopia , Transtornos Miotônicos/complicações , Sons Respiratórios/etiologia , Disfunção da Prega Vocal/etiologia
13.
Acta Clin Belg ; 73(1): 1-6, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29088983

RESUMO

OBJECTIVES: Non-dystrophic myotonia, periodic paralysis and, to a certain extent, myotonic dystrophies are rare hereditary skeletal muscle channelopathies, charactarized by myotonia or episodic muscle weakness. This review highlights the diagnostic challenges and treatment options. RESULTS: Some of these rare skeletal muscle disorders are associated with a broad range of systemic and nonspecific muscle symptoms. Consequently, patients are often referred to the internist before seeing a neurologist. This article provides clinical clues to better diagnose an tackle these unique disorders. CONCLUSION: A increased knowledge will reduce the diagnostic delay, improve monitoring and treatment, and might even prevent potentially life-threatening conditions as seen in DM.


Assuntos
Canalopatias/diagnóstico , Transtornos Miotônicos/diagnóstico , Paralisias Periódicas Familiares/diagnóstico , Canalopatias/terapia , Humanos , Medicina Interna , Transtornos Miotônicos/terapia , Paralisias Periódicas Familiares/terapia
14.
J Pediatr ; 188: 181-185.e6, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28662944

RESUMO

OBJECTIVE: To ascertain the presenting symptoms of children with skeletal muscle channelopathies to promote early diagnosis and treatment. STUDY DESIGN: Retrospective case review of 38 children with a skeletal muscle channelopathy attending the specialist pediatric neuromuscular service at Great Ormond Street Hospital over a 15-year period. RESULTS: Gait disorder and leg cramps are a frequent presentation of myotonic disorders (19 of 29). Strabismus or extraocular myotonia (9 of 19) and respiratory and/or bulbar symptoms (11 of 19) are common among those with sodium channelopathy. Neonatal hypotonia was observed in periodic paralysis. Scoliosis and/or contractures were demonstrated in 6 of 38 children. School attendance or ability to engage fully in all activities was often limited (25 of 38). CONCLUSIONS: Children with skeletal muscle channelopathies frequently display symptoms that are uncommon in adult disease. Any child presenting with abnormal gait, leg cramps, or strabismus, especially if intermittent, should prompt examination for myotonia. Those with sodium channel disease should be monitored for respiratory or bulbar complications. Neonatal hypotonia can herald periodic paralysis. Early diagnosis is essential for children to reach their full educational potential.


Assuntos
Canalopatias/complicações , Transtornos Miotônicos/diagnóstico , Canais de Sódio/genética , Absenteísmo , Adolescente , Obstrução das Vias Respiratórias , Canalopatias/diagnóstico , Criança , Pré-Escolar , Contratura/etiologia , Diplopia/etiologia , Feminino , Transtornos Neurológicos da Marcha , Humanos , Lactente , Recém-Nascido , Masculino , Cãibra Muscular/etiologia , Hipotonia Muscular/etiologia , Transtornos Miotônicos/genética , Canal de Sódio Disparado por Voltagem NAV1.4/genética , Sons Respiratórios/etiologia , Estudos Retrospectivos , Escoliose/etiologia , Estrabismo/etiologia
15.
Rev. lab. clín ; 9(4): 195-202, oct.-dic. 2016. tab, ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-158438

RESUMO

La miotonía congénita es la forma más común de miotonía no distrófica. Esta miopatía está causada por mutaciones en el gen CLCN1, codificante del principal canal de iones cloruro del músculo esquelético (ClC-1); la alteración de la función de este canal, regulado por voltaje, da lugar al fenómeno de miotonía. La enfermedad se puede heredar con un tipo de herencia dominante (enfermedad de Thomsen) o recesiva (enfermedad de Becker o miotonía congénita generalizada). El fenotipo clínico de ambas formas de la enfermedad es similar aunque la forma recesiva se caracteriza por una mayor gravedad de los síntomas. El diagnóstico clínico de miotonía congénita debe sospecharse cuando encontramos en un paciente episodios de rigidez muscular (miotonía), remisión o alivio de la rigidez con el ejercicio (fenómeno warm-up), miotonía clínica, un patrón electromiográfico característico y/o historia familiar. El diagnóstico molecular de miotonía congénita consiste en el análisis por secuenciación del gen CLCN1 (AU)


Myotonia congenita is the most common form of non-dystrophic myotonia. This myopathy is caused by mutations in the CLCN1 gene, encoding the main skeletal muscle chloride ion channel (ClC-1). Altering the function of this voltage-gated channel, leads to the phenomenon of myotonia. The disease can be inherited with a dominant (Thomsen disease) or recessive type (Becker disease or congenital generalised myotonia). The clinical phenotype of both forms of the disease is similar, although the recessive form is characterised by more severe symptoms. The clinical diagnosis of congenital myotonia should be suspected in a patient who presents with episodes of muscle stiffness (myotonia), remission or relief from stiffness with exercise (warm-up phenomenon), and a characteristic electromyography pattern, and/or family history. Sequencing the CLCN1 gene is the present approach for molecular diagnosis of myotonia congenita (AU)


Assuntos
Humanos , Masculino , Feminino , Miotonia Congênita/diagnóstico , Miotonia Congênita/genética , Miosite/complicações , Miosite/diagnóstico , Mutagênese/genética , Biologia Molecular/métodos , Diagnóstico Diferencial , Diagnóstico Clínico/diagnóstico , Diagnóstico Clínico/tendências , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Distrofia Muscular de Duchenne/complicações , Distrofia Muscular de Duchenne/diagnóstico
16.
Neuromuscul Disord ; 25(1): 73-80, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25454733

RESUMO

Non-dystrophic myotonic syndromes represent a heterogeneous group of clinically quite similar diseases sharing the feature of myotonia. These syndromes can be separated into chloride and sodium channelopathies, with gene-defects in chloride or sodium channel proteins of the sarcolemmal membrane. Myotonia has its basis in an electrical instability of the sarcolemmal membrane. In the present study we examine the discriminative power of the resulting myotonic discharges for these disorders. Needle electromyography was performed by an electromyographer blinded for genetic diagnosis in 66 non-dystrophic myotonia patients (32 chloride and 34 sodium channelopathy). Five muscles in each patient were examined. Individual trains of myotonic discharges were extracted and analyzed with respect to firing characteristics. Myotonic discharge characteristics in the rectus femoris muscle almost perfectly discriminated chloride from sodium channelopathy patients. The first interdischarge interval as a single variable was longer than 30 ms in all but one of the chloride channelopathy patients and shorter than 30 ms in all of the sodium channelopathy patients. This resulted in a detection rate of over 95%. Myotonic discharges of a single muscle can be used to better guide toward a molecular diagnosis in non-dystrophic myotonic syndromes.


Assuntos
Canalopatias/diagnóstico , Canalopatias/fisiopatologia , Canais de Cloreto/genética , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/fisiopatologia , Canal de Sódio Disparado por Voltagem NAV1.4/genética , Adulto , Idoso , Canalopatias/genética , Eletromiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/fisiopatologia , Transtornos Miotônicos/genética , Adulto Jovem
18.
Neurol Clin ; 32(3): 801-15, x, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25037091

RESUMO

Skeletal muscle channelopathies are rare heterogeneous diseases with marked genotypic and phenotypic variability. Despite advances in understanding of the molecular pathology of these disorders, the diverse phenotypic manifestations remain a challenge in diagnosis and therapeutics. These disorders can cause lifetime disability and affect quality of life. There is no treatment of these disorders approved by the US Food and Drug Administration at this time. Recognition and treatment of symptoms might reduce morbidity and improve quality of life. This article summarizes the clinical manifestations, diagnostic studies, pathophysiology, and treatment options in nondystrophic myotonia, congenital myasthenic syndrome, and periodic paralyses.


Assuntos
Canalopatias/diagnóstico , Canais Iônicos/genética , Canalopatias/genética , Canalopatias/fisiopatologia , Canalopatias/terapia , Humanos , Músculo Esquelético/metabolismo , Músculo Esquelético/fisiopatologia , Mutação , Síndromes Miastênicas Congênitas/diagnóstico , Síndromes Miastênicas Congênitas/genética , Síndromes Miastênicas Congênitas/fisiopatologia , Miotonia/diagnóstico , Miotonia/genética , Miotonia/fisiopatologia , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Transtornos Miotônicos/fisiopatologia
19.
Curr Neurol Neurosci Rep ; 14(2): 429, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24435591

RESUMO

Myotonic dystrophy is the commonest adult muscular dystrophy. Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are often discussed jointly, and although they share many clinical and molecular features, differences do exist. Historically, more is known about DM1 than about DM2. The literature in the field of myotonic dystrophy is broad, with advances in our understanding of DM2. This article reviews recent developments in DM2 with respect to diagnosis, systemic features, and molecular mechanisms of the disease.


Assuntos
Transtornos Miotônicos , Animais , Feminino , Humanos , Masculino , Transtornos Miotônicos/diagnóstico , Transtornos Miotônicos/genética , Transtornos Miotônicos/fisiopatologia , Distrofia Miotônica
20.
Muscle Nerve ; 49(2): 277-83, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23716346

RESUMO

INTRODUCTION: Standard electromyography (EMG) is useful in the diagnosis of myotonic dystrophy type 1 (DM1) and type 2 (DM2), but it does not differentiate between them. The aim of this study was to estimate the utility of the short exercise test (SET) and short exercise test with cooling (SETC) in differentiating between DM1 and DM2. METHODS: SET and SETC were performed in 32 patients with DM1 (mean age 35.8 ± 12.7 years) and 28 patients with DM2 (mean age 44.5 ± 12.5 years). RESULTS: We observed a significant decline in compound motor action potential (CMAP) amplitude in DM1 with both SET and SETC immediately after effort. In DM2, there was no marked change in CMAP amplitude with either SET or SETC. CONCLUSIONS: SET and SETC may serve as useful tools for clinical differentiation between DM1 and DM2, and they may be used as a guide for molecular testing.


Assuntos
Testes Diagnósticos de Rotina/métodos , Teste de Esforço/métodos , Exercício Físico/fisiologia , Transtornos Miotônicos/diagnóstico , Distrofia Miotônica/diagnóstico , Potenciais de Ação/fisiologia , Adulto , Diagnóstico Diferencial , Fenômenos Eletrofisiológicos , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/fisiopatologia , Transtornos Miotônicos/fisiopatologia , Distrofia Miotônica/fisiopatologia
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