Assuntos
Síndrome de Creutzfeldt-Jakob/fisiopatologia , Transtornos dos Movimentos/etiologia , Transtornos Psicofisiológicos/etiologia , Proteínas 14-3-3/líquido cefalorraquidiano , Síndrome de Creutzfeldt-Jakob/líquido cefalorraquidiano , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos dos Movimentos/líquido cefalorraquidiano , Transtornos Psicofisiológicos/líquido cefalorraquidianoRESUMO
15 patients with psychosomatic disease, 26 patients with miscellaneous neurological diseases, and 16 patients with cerebrovascular disease were investigated with regard to concentrations of ferritin in serum and cerebrospinal fluid (CSF). The mean CSF ferritin concentration in the psychosomatic group was 6.2 micrograms/l +/- 2.4 (1 S.D.). Patients with recent cerebral infarction had similar values while 2 patients with intracerebral hematomas had very high CSF ferritin concentrations. There was a positive correlation between serum and CSF ferritin levels and between CSF total protein and ferritin in patients with a damaged blood-CSF barrier only. At present, the practical value of analysing ferritin in the CSF is very small.
Assuntos
Transtornos Cerebrovasculares/líquido cefalorraquidiano , Ferritinas/líquido cefalorraquidiano , Doenças do Sistema Nervoso/líquido cefalorraquidiano , Transtornos Psicofisiológicos/líquido cefalorraquidiano , Barreira Hematoencefálica , Hemorragia Cerebral/líquido cefalorraquidiano , Infarto Cerebral/líquido cefalorraquidiano , Hematoma/líquido cefalorraquidiano , HumanosAssuntos
Endorfinas/fisiologia , Dor/fisiopatologia , Animais , Comportamento , Endorfinas/análise , Feminino , Cobaias , Humanos , Transtornos Mentais/líquido cefalorraquidiano , Camundongos , Dor/líquido cefalorraquidiano , Gravidez , Transtornos Psicofisiológicos/líquido cefalorraquidiano , Ratos , Receptores Opioides/análiseAssuntos
Aminas Biogênicas/líquido cefalorraquidiano , Endorfinas/líquido cefalorraquidiano , Dor/líquido cefalorraquidiano , Adulto , Idoso , Doença Crônica , Feminino , Ácido Homovanílico/líquido cefalorraquidiano , Humanos , Ácido Hidroxi-Indolacético/líquido cefalorraquidiano , Masculino , Pessoa de Meia-Idade , Dor/etiologia , Dor/psicologia , Transtornos Psicofisiológicos/líquido cefalorraquidianoRESUMO
In 45 consecutive patients with chronic pain syndromes endorphins, fraction I of the cerebrospinal fluid and pain measures by means of electric stimulation via saline electrodes were investigated. In patients with high levels of fraction I (above median) pain threshold, PT and tolerance level, TL, in condition C (continuous stimulation increase) were found to be significantly higher than in patients with low levels of fraction I (below median). The results indicate that the endorphins are one of the physiological factors that contribute to the pain threshold and the tolerance level.
Assuntos
Endorfinas/líquido cefalorraquidiano , Dor/líquido cefalorraquidiano , Adulto , Doença Crônica , Estimulação Elétrica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Psicofisiológicos/líquido cefalorraquidiano , Limiar Sensorial , Fatores SexuaisRESUMO
A series of 37 patients with chronic pain was investigated with regard to neurologic and psychiatric variables. Twenty of the patients were classified as having mainly organic (= somatogenic) pain syndromes while 17 patients were rather suffering from psychogenic pain syndromes. Samples of lumbar cerebrospinal fluid (CSF) were obtained from the patients and analyzed for the presence of opiate receptor-active material, here called endorphins. Patients classified as having mainly organic pain syndromes were found to have significantly lower endorphin levels than patients with predominantly psychogenic pain syndromes. In the total group of patients as well as in the two subgroups, there was a significant correlation between CSF endorphin levels and the depth of depressive symptomatology as reported by the patients. On the other hand, there was no correlation between CSF endorphin levels and extent of anxiety or motor retardation. It is concluded that CSF endorphins reflect central processes involved in chronic pain syndromes.
