RESUMO
A researcher, a 40 year-old male, was bitten on his finger accidentally by a 75 cm long, adult male blunt-nosed viper, Macrovipera lebetina lebetina (Linnaeus) that had been collected from northern Cyprus during laboratory work in the Zoology Section, Biology Department of the Ege University Faculty of Science. The clinical signs, physiological and biochemical changes soon after the venomous bite by the blunt-nosed viper as well as the electrophoretic separation of plasma proteins of the patient have been presented here. Serious important symptoms (edema, hypotension shock, hemorrhage, tissue necrosis, and melanoderma) developed and major quantitative differences in the fractions of albumin, globulin and albumin/globulin ratios were detected. On the other hand, the measurements carried out in blood smears and biochemical results indicated the decrease in RBC, MCV, MHV and a decrease in the diameter of red blood cells, as well as an increase in WBC.
Assuntos
Proteínas Sanguíneas/análise , Traumatismos dos Dedos/fisiopatologia , Mordeduras de Serpentes/fisiopatologia , Viperidae , Adulto , Animais , Análise Química do Sangue , Eletroforese das Proteínas Sanguíneas , Proteínas Sanguíneas/química , Densitometria , Edema/etiologia , Traumatismos dos Dedos/sangue , Testes Hematológicos , Hemorragia/etiologia , Humanos , Masculino , Necrose , Choque/etiologia , Mordeduras de Serpentes/sangue , Mordeduras de Serpentes/terapiaRESUMO
A finger-stick office test for measuring serum lithium concentrations.
Assuntos
Monitoramento de Medicamentos/instrumentação , Traumatismos dos Dedos/sangue , Lítio/sangue , Ferimentos Penetrantes Produzidos por Agulha/sangue , Custos e Análise de Custo , Monitoramento de Medicamentos/economia , Monitoramento de Medicamentos/métodos , Humanos , Lítio/toxicidade , Reprodutibilidade dos TestesRESUMO
To investigate the significance of activated platelet levels before and after surgical operation in patients with severed finger by severe injury, the P-selectin (CD62p) positive platelet percent in peripheral blood was studied in 32 patients before and after operation by flow cytometric immunology. At the second and third day after operation, seventeen patients, which in a high positive platelet percent, were measured again after anticoagulation treatment with a large dose of urokinase etc. The results were that the levels of CD62p positive platelet in peripheral blood before and after operation were significantly higher than that of the normal group (P < 0.01). The CD62p positive platelet percent was increased not much more in the anti-coagulation patients than in the normal ones (P > 0.05). There were a few vascular crisis observed. This study suggested that severed fingers by a crushing or wringing injury enhance the platelet activity and resulted in hypercoagulation, thus anti-coagulation measures should be taken to avoid possible thrombosis and improve the survival rate of replantation. CD62p was one of the sensitive indices of activated platelet, which could be used in calculating hypercoagulation accurately.
