[Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide]. / Magnitoupravliaemye anestetiki na osnove vysokodispersnykh poroshkov zheleza s poliakrilamidnym pokrytiem.

The effect of external magnetic field (direct and alternating) on the targeted delivery and distribution in body tissues of experimental animals of anesthetics (novocain, lidocaine, and trimecaine) immobilized on highly dispersed ferromagnetics with biocompatible coating was studied by the method of emission spectral analysis. The results are compared with the results obtained earlier on highly dispersed iron powders with dextran coating. The parameters for the powders with dextran coating are considerably lower than those for the magnetic carriers with the polyacrylamide coating.

Percutaneous absorption of disopyramide, lidocaine and trimecaine.

Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrythmics drugs disopyramide, lidocaine and trimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement. The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in 1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Other cyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.

[Distribution of anesthetics immobilized on finely dispersed iron powders in the organism of experimental animals]. / Raspredelenie immobilizovannykh na vysokodispersnykh poroshkakh zhelezaanestetikov v organizme eksperimental'nykh zhivotnykh.

Directed delivery and distribution of anaesthetics (novocaine, lidocaine, trimecaine) immobilized on finely dispersed iron powders under the influence of an external magnetic field in body tissues of test animals have been studied. The data of emission spectral analysis relating to concentration of iron in soft and bone tissues of animals influenced by constant and alternating magnetic field on front and reverse sides over a period from 0 to 180 min are given.

[Anatomic distribution of anesthetic solutions in the orbit after subconjuctival, parabulbar and retrobulbar administration]. / Anatomická distribúcia anestetického roztoku v orbite pri subkonjunktiválnej, parabulbárnej a retrobulbárnej aplikácii.

Authors evaluated anatomical distribution of 1% Mesocain solution with subconjuctival (SC), parabulbar (PB) and retrobulbar (RB) applications by ultrasonographic orbital examination. At SC application was not expressive mobilization of bolus. At PB and RB applications were observed dependence between bolus dislocation (mm) and quantity injected bolus (ml). At PB and RB applications were recorded expressive mobilization of injected bolus at orbit.

[The local anesthetic activity of inclusion compounds of pirbentan and trimecaine with beta-cyclodextrin]. / Issledovanie mestnoanesteziruiushchei aktivnosti soedinenii vkliucheniia porbentana i trimekaina s beta-tsiklodekstrinom.

Whether the prolonged action of the topical anesthetics trimecaine and pirbentan can be achieved by using inclusion compounds was studied. beta-Cyclodextrin was used as an agent containing topical anesthetics in its molecule. In in vitro and in vivo experiments, the inclusion compounds trimecaine and pirbentan with beta-cyclodextrin produced a more prolonged action in terminal anesthesia than the compounds used alone.

[Changes in pharmacokinetics of trimecaine in patients with liver cirrhosis]. / Zmeny farmakokinetiky trimekainu u nemocných s jaterní cirhózou.

Trimecaine (Mesocain, Léciva) an analogous preparation to lidocaine is used as a local anaesthetic, antiarrhythmic and spasmolytic preparation. The purpose of the investigation was to assess the fate of trimecaine in nine patients with compensated cirrhosis of the liver. The pharmacokinetics were evaluated after intravenous infusion of trimecaine administered at a rate of 150-200 mg.h-1. Plasma concentrations of the drug evaluated by gas chromatography indicate a marked retardation of trimecaine elimination in patients with liver damage. In the group of patients with cirrhosis of the liver the total clearance of the drug was lower (8.7 +/- 5.0 1.h-1), as compared with the group of patients without liver damage (34.7 +/- 19.4 1.h-1). In patients with cirrhosis of the liver also a multiple reduction of distribution volumes was observed. The results indicate a high hepatic extraction of