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2.
Scand J Immunol ; 27(1): 31-4, 1988 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-3124260

RESUMO

The lectins from Datura stramonium, Lycopersicon esculentum, and Solanum tuberosum are structurally related and possess a similar carbohydrate specificity, yet the Datura lectin is mitogenic for human lymphocytes while the other two are not. However, the Datura lectin was found to antagonize blast transformation induced by purified protein derivative (PPD), even within the concentration range at which it was optimally mitogenic on its own. The presence of a submitogenic concentration of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) enormously enhanced the mitogenic activity of Datura lectin. No such synergy was observed, however, between tomato lectin or S. tuberosum agglutinin (STA) and TPA, nor between Datura lectin and the calcium ionophore A 23187.


Assuntos
Lectinas/farmacologia , Ativação Linfocitária/efeitos dos fármacos , Calcimicina/farmacologia , Datura stramonium , Sinergismo Farmacológico , Humanos , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/imunologia , Lectinas de Plantas , Plantas Medicinais , Plantas Tóxicas , Acetato de Tetradecanoilforbol/farmacologia , Tuberculina/antagonistas & inibidores , Tuberculina/farmacologia
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