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1.
BMC Urol ; 21(1): 125, 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34503465

RESUMO

BACKGROUND: Genitourinary tuberculosis (GUTB) is known to cause high rates of structural organ damage, however, literature on its biochemical manifestations is limited. Additionally, local studies in the Philippine setting, where cases are rampant, are few and dated. This study aimed to determine the serologic and urinary profile of patients with GUTB admitted at a tertiary hospital within January 2009 to March 2020 and their association with short-term outcomes. METHODS: This retrospective study included 112 patients with laboratory-confirmed GUTB (i.e., positivity in acid-fast smear, polymerase chain reaction, culture, or histology). Demographic data, clinical characteristics, laboratory and radiologic findings, histopathology reports, treatment, and short-term outcomes were recorded. RESULTS: Bladder (54.5%) and kidney (36.4%) were the most affected organs. The male:female ratio was 1:1.15, and the mean age was 35.79 ± 18.29 years. Weakness (14.29%) was the most common chief complaint. A majority presented with anemia (83.04%), while several had leukocytosis (41.96%) and thrombocytosis (26.79%). Hypoalbuminemia (58.10%), impairment of renal function (36.94%), and electrolyte abnormalities such as hyponatremia (50.93%), hypercalcemia (20.19%), and hypokalemia (21.82%) were common. Proteinuria (67.96%) and pyuria (67.96%) were the most frequent abnormal findings, followed by hematuria (51.46%), acidic urine (45.63%) and low specific gravity (31.07%). Age, leukocytosis, and the need for pressors were all significantly associated with mortality (p values of <0.001, 0.010, and <0.001, respectively). CONCLUSIONS: The young age at presentation with severe clinical and laboratory manifestations may reflect local epidemiology as TB continues to be widespread in the country. Apart from the more commonly cited abnormalities in literature, multiple electrolyte imbalances and urinary concentration defects were also observed in many cases, possibly indicating tubulointerstitial involvement-a complication increasingly mentioned in case reports. As several patient characteristics were found to be associated with the high mortality rates observed in the study, further research is recommended to explore predictive modeling.


Assuntos
Tuberculose Urogenital/sangue , Tuberculose Urogenital/urina , Adolescente , Adulto , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Anemia/etiologia , Criança , Pré-Escolar , Feminino , Humanos , Hipoalbuminemia/etiologia , Hipopotassemia/etiologia , Lactente , Recém-Nascido , Leucocitose/etiologia , Masculino , Pessoa de Meia-Idade , Filipinas , Estudos Retrospectivos , Centros de Atenção Terciária , Trombocitose/etiologia , Resultado do Tratamento , Tuberculose Urogenital/complicações , Tuberculose Urogenital/terapia , Adulto Jovem
2.
Epidemiol Mikrobiol Imunol ; 67(2): 55-57, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30126281

RESUMO

The study aim was to determine whether there is a correlation between subclinical forms of genitourinary tuberculosis (GUTB) and immune status. All patients admitted to the Pneumology Clinic of the Thomayer Hospital, Prague with lung tuberculosis (LTB) were enrolled in the study. The study group consisted of 102 patients, 75 males and 27 females, median age of 46.8 years. In a previously published part of the study, 6.9 % of LTB patients were diagnosed with subclinical forms of GUTB. In the present part of the study, immune status was determined in patients with subclinical forms of GUTB by measuring circulating immunoglobulin G and CD4 T cell levels. The comparison of the immunological results did not show a statistically significant difference between the patients diagnosed with GUTB and other LTB patients..


Assuntos
Tuberculose Urogenital , Adulto , Contagem de Linfócito CD4 , Feminino , Humanos , Imunoglobulina G/sangue , Masculino , Pessoa de Meia-Idade , Tuberculose Pulmonar/sangue , Tuberculose Pulmonar/imunologia , Tuberculose Urogenital/sangue , Tuberculose Urogenital/imunologia
3.
Int J Tuberc Lung Dis ; 9(7): 822-4, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16013782

RESUMO

We report two human leukocyte antigen (HLA) B27-positive cases of urogenital tuberculosis (TB) with asymmetric polyarthritis. Stained smears with Ehrlich Ziehl-Neelsen and polymerase chain reaction (PCR) tests for Mycobacterium tuberculosis complex (MTC) of the ejaculate were positive in both cases, despite negative cultures. Stained smear, culture and PCR results of the synovial fluid for mycobacteria were negative. The patients were diagnosed with Poncet's disease. Polyarthritis was resolved rapidly with anti-tuberculosis treatment. We suggest that in cases with unexplained arthritis and non-articular TB, Poncet's disease should be considered. PCR can be used in the routine diagnostic algorithm when conventional methods fail to identify MTC.


Assuntos
Artrite Reativa/epidemiologia , Tuberculose Urogenital/epidemiologia , Adulto , Artrite Reativa/tratamento farmacológico , Sedimentação Sanguínea , Proteína C-Reativa/análise , Antígeno HLA-B27/análise , Humanos , Masculino , Reação em Cadeia da Polimerase , Tuberculose Urogenital/sangue , Tuberculose Urogenital/diagnóstico
4.
Probl Tuberk Bolezn Legk ; (1): 5-8, 2004.
Artigo em Russo | MEDLINE | ID: mdl-15137134

RESUMO

The incidence of extrapulmonary tuberculosis has been studied in children and adolescents in the Primorye Territory in 1996 to 2001. There is a decrease in the incidence and prevalence of extrapulmonary tuberculosis in both children and adolescents, which does not reflect the true situation as the process is more frequently diagnosed on their referral in the period of late clinical manifestations. Young age children have fallen ill more frequently (54.7%); 76% of the patients were identified on their referral. Most children are permanent residents and live in the high- and middle-class families. In the clinical pattern, there were predominant ostcoarticular forms of tuberculosis running with a complication of the underlying disease in 80%. The study suggests that there are great gaps in the detection of extrapulmonary tuberculosis in children.


Assuntos
Tuberculose dos Linfonodos/epidemiologia , Tuberculose Osteoarticular/epidemiologia , Tuberculose Urogenital/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Prevalência , Federação Russa/epidemiologia , Tuberculose dos Linfonodos/sangue , Tuberculose dos Linfonodos/diagnóstico , Tuberculose Osteoarticular/sangue , Tuberculose Osteoarticular/diagnóstico , Tuberculose Urogenital/sangue , Tuberculose Urogenital/diagnóstico
5.
Probl Tuberk ; (2): 41-3, 1998.
Artigo em Russo | MEDLINE | ID: mdl-9613187

RESUMO

Laser therapy was performed in 45 patients with tuberculosis of the urinary system and male genitals. The radiation was found to have a positive action on the patients' general condition and short-term immunomodulating effect. Following a month, immunological parameters became baseline or near-baseline. In the course of 5 years there was an exacerbation of tuberculosis in 2 (4 +/- 3%) patients who had received laser therapy and in 8-18% routinely treated without laser therapy.


Assuntos
Sangue/efeitos da radiação , Terapia a Laser , Tuberculose Urogenital/radioterapia , Adulto , Idoso , Linfócitos B/imunologia , Linfócitos B/efeitos da radiação , Terapia Combinada , Feminino , Seguimentos , Humanos , Imunoglobulinas/sangue , Imunoglobulinas/efeitos da radiação , Masculino , Pessoa de Meia-Idade , Linfócitos T/imunologia , Linfócitos T/efeitos da radiação , Resultado do Tratamento , Tuberculose Urogenital/sangue , Tuberculose Urogenital/imunologia
7.
Urol Nefrol (Mosk) ; (1): 19-22, 1990.
Artigo em Russo | MEDLINE | ID: mdl-2336752

RESUMO

Osmolarity and its constituents were followed up during the treatment course in 43 patients with tuberculosis of the urinary system and in 14 controls. The authors confirmed the relation of the blood and urinary osmolarity to the stage of chronic renal failure (CRF). CRF aggravation was evidenced by the development of hypo-osmolarity in the urine and a progressing decrease in the ratio coefficient between the osmolarity in the urine and in the plasma. Stability of plasma hyperosmolarity continued to be more than 340 mosmol/kg H2O and a decrease in the aforementioned coefficient to less than 1 despite the treatment evidenced the terminal stage of CRF and unfavourable outcome of surgical intervention.


Assuntos
Falência Renal Crônica/sangue , Falência Renal Crônica/urina , Tuberculose Urogenital/sangue , Tuberculose Urogenital/urina , Adulto , Humanos , Falência Renal Crônica/cirurgia , Pessoa de Meia-Idade , Concentração Osmolar , Período Pós-Operatório , Potássio/análise , Sódio/análise , Tuberculose Urogenital/cirurgia
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