RESUMO
No disponible
Assuntos
Humanos , Criança , Hélio/administração & dosagem , Insuficiência Respiratória/terapia , Respiração Artificial/métodos , Fadiga Muscular/fisiologia , Terapia Respiratória/métodos , Ventilação de Alta Frequência/métodos , Unidades de Terapia Intensiva Pediátrica/métodos , Cuidados Críticos/métodosRESUMO
No disponible
Assuntos
Humanos , Criança , Estado Epiléptico/tratamento farmacológico , Anticonvulsivantes/uso terapêutico , Unidades de Terapia Intensiva Pediátrica/métodos , Cuidados Críticos/tendências , Aprovação de Drogas/métodos , Interações Medicamentosas , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controleRESUMO
Mechanically ventilated children usually require a combination of sedation (morphine = M, diazepam = D) and paralysis (pancuronium = P) to minimize anxiety, discomfort, and the risks of self-extubation, tracheal injury, and pulmonary barotrauma. We sought to determine whether our use of MDP varied with patient age. Cases where the dosage of MDP would be influenced by neurological, hemodynamic, or painful diagnoses were excluded. The 36 cases selected were divided according to age into three groups (less than 4 months = A, 4-18 months = B, greater than 18 months = C). The daily sum of MDP dosages was calculated for each of the 326 study days, a mean of 9 study days for each case. The median daily drug usage in group B (2.3 mg/kg/day) was twice that in either group A (younger) or group C (older) (both p less than 0.001). This finding may be explained by developmental changes in physiology, pharmacology, and behavior, and may have been influenced by a paradoxical drug effect or multiple drug antagonism.
