1.
Photochem Photobiol
; 53(2): 169-74, 1991 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1707176
RESUMO
Hypericin, a photoreactive polycyclic quinone, was found to dramatically reduce infectivity of cell-free stocks of equine infectious anemia virus. However, the antiviral activity of hypericin was completely dependent on the presence of light. Short periods of photosensitization resulted in a partial loss of reverse transcriptase activity and complete inhibition of viral infectivity. These results suggest that the photodynamic effect of hypericin interferes with more than one stage in the virus replication cycle.
Assuntos
Antivirais/farmacologia , Vírus da Anemia Infecciosa Equina/efeitos dos fármacos , Perileno/análogos & derivados , Radiossensibilizantes/farmacologia , Antracenos , Escuridão , Vírus da Anemia Infecciosa Equina/fisiologia , Vírus da Anemia Infecciosa Equina/efeitos da radiação , Luz , Perileno/farmacologia , Inibidores da Transcriptase Reversa , Relação Estrutura-Atividade
2.
Arch Gesamte Virusforsch
; 41(1): 135-7, 1973.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4352062