RESUMO
Aromatic derivatives of mevalonic acid (2-phenyl-3-methyl-3-hydroxy pentanic and 2,3-diphenyl-3-hydroxy pentanic acids) decreased the yield of unesterified fatty acids from adipose tissue by about 28-36 percent after subcutaneous administration into rats within one or two weeks and under conditions of incubation of the adipose tissue in vitro. Distinct decrease in the yield of glycerol was cause by 2,3-diphenyl-3-hydroxy pentanic acid (1 with 10-minus 3 = 5 with 10-minus 3 M) under conditions of lipolysis stimulated by adrenaline. Antilipolytic effect of the preparation was more pronounced than that of well-known hypolipidemic drug clofibrate (p-chlorophenhydroxy isobutyrate).
Assuntos
Tecido Adiposo/efeitos dos fármacos , Metabolismo dos Lipídeos , Ácidos Pentanoicos/análogos & derivados , Valeratos/análogos & derivados , Tecido Adiposo/metabolismo , Animais , Clofibrato/farmacologia , Epididimo/efeitos dos fármacos , Epididimo/metabolismo , Ácidos Graxos não Esterificados/metabolismo , Glicerol/metabolismo , Técnicas In Vitro , Injeções Subcutâneas , Masculino , Ácido Mevalônico/farmacologia , Ácidos Pentanoicos/farmacologia , Ratos , Fatores de TempoRESUMO
It was shown that oxygen at high pressure (OHP) induced epileptic seizures and pulmonary damages on mice. Dipropylacetate protected mice against nervous syndrome better than did dipropylacetamide. No significant pulmonary protection was observed with both drugs.