RESUMO
The study deals with the possible etiological role of Chlamydia, Mycoplasma, Ureaplasma, and bacteroid infections in the development of chronic conjunctivitis and dry eye (DE). A hundred and fifty patients with DE and chronic conjunctivitis were examined. Conjunctival scrapes were examined by direct immunofluorescence for evidence of Chlamydia, Mycoplasma, Ureaplasma, and bacteroid infections. DE was verified by the Schirmer test and the Norn test. Ninety-five (63.3%) persons were found to be infected. GE was diagnosed in 84 (56%) of the 150 patients. Analysis of infection rates revealed Chlamydia, Mycoplasma, Ureaplasma as mono- and mixed infection in 63.3, 50.6, and 35.3, respectively, and bacteroids as mixed infection in 32.6%. Chlamydia was detected in the conjunctiva in the vast majority of patients with DE (90.5%). Chlamydia infection of the conjunctiva is one of the causes of artificial DE. Conjunctival Chlamydia affliction is manifested by the clinical picture of chronic slowly progressive inflammation with the progression of DE after a latent period of about 2-3 years.
Assuntos
Infecções por Chlamydia , Conjuntivite/microbiologia , Xeroftalmia/microbiologia , Adulto , Chlamydia/isolamento & purificação , Infecções por Chlamydia/complicações , Infecções por Chlamydia/diagnóstico , Doença Crônica , Túnica Conjuntiva/microbiologia , Conjuntivite/etiologia , Progressão da Doença , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Masculino , Pessoa de Meia-Idade , Mycoplasma/isolamento & purificação , Ureaplasma/isolamento & purificação , Xeroftalmia/diagnóstico , Xeroftalmia/etiologiaAssuntos
Túnica Conjuntiva/microbiologia , Infecções por Corynebacterium/microbiologia , Corynebacterium/isolamento & purificação , Infecções Oculares Bacterianas/microbiologia , Xeroftalmia/microbiologia , Corynebacterium/classificação , Infecções por Corynebacterium/história , Infecções Oculares Bacterianas/história , História do Século XV , História do Século XVI , História do Século XVII , História do Século XVIII , História do Século XIX , História do Século XX , História do Século XXI , História Antiga , História Medieval , Humanos , Xeroftalmia/históriaRESUMO
The concentrations of tear lysozyme, lactoferrin, ceruloplasmin, IgA, and IgG have been estimated in patients with dry eyes at the same time as semiquantitative bacterial culture was performed of the conjunctivae and lids. Staphylococcal isolations were quantified and biotyped. There was no increased conjunctival colonisation by any particular biotype of Staphylococcus aureus or Staph. epidermidis, and similar numbers of conjunctivae were sterile as in controls (33%); neither were any pathogens such as pneumococci or haemophili isolated. We consider that the conjunctiva of the dry eye, without the lacrimal secretion components of lysozyme and lactoferrin, has an alternative protective antibacterial mechanism which is derived from serum proteins via chronically inflamed vessels.
Assuntos
Proteínas/análise , Lágrimas/análise , Xeroftalmia/microbiologia , Adulto , Idoso , Ceruloplasmina/análise , Túnica Conjuntiva/microbiologia , Pálpebras/microbiologia , Humanos , Imunoglobulina A/análise , Imunoglobulina G/análise , Ceratoconjuntivite Seca/microbiologia , Lactoferrina/análise , Pessoa de Meia-Idade , Muramidase/análise , Staphylococcus aureus/isolamento & purificação , Staphylococcus epidermidis/isolamento & purificaçãoRESUMO
Extraocular bacterial culture was performed in 100 patients with hypovitaminosis A xerophthalmia. There was corneal ulceration in 29 cases and corneal perforation in 22 cases. Eighty-six percent of the patients harbored frankly pathogenic bacteria (46 patients) and potentially pathogenic bacteria (40 patients). All but two patients with either cornal ulceration or perforation harbored potentially pathogenic or frankly pathogenic bacteria. Pseudomonas aeruginosa, Diplococcus pneumoniae, and Moraxella species were isolated in 37% (19 patients) of cases with corneal ulceration and perforation. I cultured P. aeruginosa from 36% (eight patients) of cases with corneal perforation. The many ocular secondary bacterial infections in the early stages of xerophthalmia seem to suggest that bacterial action plays a major role in causing the corneal ulceration and perforation in hypovitaminosis A xerophthalmia.
