RESUMO
Although meninges represent a major site of biosynthesis, beta-trace protein (beta-trace) has not been studied in the cerebrospinal fluid (CSF) of meningitis patients. We measured beta-trace in lumbar CSF of normal controls (n = 27) and in patients with various neurological diseases (n = 92) by an immunonephelometric assay. The mean concentration of beta-trace in CSF of control patients was 16.6+/-3.6 mg/l. In bacterial meningitis (n = 41), CSF beta-trace was significantly decreased (8.7+/-3.9 mg/l; P< 0.001), whereas in spinal canal stenosis it was elevated (29.2+/-10.3 mg/l; P= 0.002). In viral meningoencephalitis (n = 12), beta-trace CSF concentrations were normal. Beta-trace concentrations remained below the normal range even after curing of bacterial meningitis, and normalisation of CSF leucocytes and blood-CSF barrier function. Beta-trace may be a useful tool for studying the pathophysiology of bacterial meningitis.
Assuntos
beta-Globulinas/líquido cefalorraquidiano , Oxirredutases Intramoleculares , Meningites Bacterianas/líquido cefalorraquidiano , Adulto , Idoso , beta-Globulinas/deficiência , Feminino , Seguimentos , Humanos , Lipocalinas , Masculino , Meningites Bacterianas/sangue , Meningite Viral/sangue , Meningite Viral/líquido cefalorraquidiano , Pessoa de Meia-Idade , Esclerose Múltipla/sangue , Esclerose Múltipla/líquido cefalorraquidiano , Polirradiculoneuropatia/sangue , Polirradiculoneuropatia/líquido cefalorraquidiano , Valor Preditivo dos Testes , Tuberculose Meníngea/sangue , Tuberculose Meníngea/líquido cefalorraquidianoAssuntos
Proteínas Sanguíneas/análise , Esofagoplastia/métodos , Adolescente , Adulto , alfa-Globulinas/deficiência , beta-Globulinas/deficiência , Eletroforese das Proteínas Sanguíneas , Criança , Colo/transplante , Seguimentos , Humanos , Íleo/transplante , Intestinos/transplante , Jejuno/transplante , Pessoa de Meia-Idade , Fatores de TempoAssuntos
Talassemia/genética , Adolescente , beta-Globulinas/deficiência , Colômbia , Feminino , Humanos , LinhagemRESUMO
The bare-lymphocyte syndrome is characterised by a combined immunodeficiency associated with the lack of expression of HLA A, B, and C antigens and the absence of beta 2 microglobulin on lymphocytes. Other antigens are present on the surface of lymphocytes. Nine case-reports have been collected by an international registry. Studies on these patients confirm the role of HLA molecules in the development of functional T lymphocytes.
Assuntos
beta-Globulinas/deficiência , Antígenos HLA/imunologia , Síndromes de Imunodeficiência/imunologia , Linfócitos/imunologia , Microglobulina beta-2/deficiência , Diferenciação Celular , Feminino , Antígenos HLA/genética , Humanos , Síndromes de Imunodeficiência/genética , Complexo Principal de Histocompatibilidade , Masculino , Linhagem , Terminologia como AssuntoRESUMO
A retrospective analysis of data from a series of 22 patients with toxic megacolon complicating ulcerative colitis was performed in an attempt to detect factors associated with the fatal outcome of the attack. Of the 25 clinical findings studied, significant differences between survivors (17) and nonsurvivors (5) were observed in only seven. In nonsurvivors, duration of the disease was longer and blood pH and standard bicarbonate levels higher, whereas serum potassium, calcium, phosphorus, and beta-globulins were lower. Discriminant analysis showed that three pairs of features, namely potassium-beta-globulins, potassium-bicarbonate, and potassium-blood pH provided a good discrimination between survivors and nonsurvivors. Results of this study indicate that the severity of the electrolyte and metabolic disorder appears to be an important risk factor in toxic megacolon. Intensive fluid and electrolyte replacement should therefore be considered a crucial point for successful management of toxic megacolon.
