Osteosarcoma of the jaw - experience at the Medical University Vienna and comparative study with international tumor registries
Clinics
; 74: e701, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1001831
Responsible library:
BR1.1
ABSTRACT
OBJECTIVES:
Osteosarcoma of the jaw (OSAJ) is fundamentally different in clinical practice from its peripheral counterparts. Studies are difficult to conduct due to low incidence rates. The primary aim of this study was to provide for the first time a comprehensive retrospective analysis of the treatment concepts and outcome data of OSAJ patients treated at the University Hospital Vienna and to compare these with two recently published studies on OSAJ. The clinical study was accompanied by a biomarker study investigating the prognostic relevance of melanoma-associated antigen-A (MAGE-A) in OSAJ specimens.METHOD:
Eighteen patients were included, and their outcomes were compared to published data. Immunohistochemistry was performed with mouse monoclonal antibodies against MAGE-A. Survival rates were estimated by the Kaplan-Meyer method. The log-rank test was used to analyze potential prognostic parameters. Fisher's exact test was performed to define the significant differences between the survival rates of the current study and the DOESAK registry.RESULTS:
Disease-specific survival was 93.8% after five and 56.3% after ten years. The development of metastases (p=0.033) or relapse (p=0.037) was associated with worsened outcomes in our group as well as in the comparative group. Despite the different treatment concepts of the study groups, survival rates were comparable. MAGE-A failed to show prognostic relevance for OSAJ patients.CONCLUSIONS:
Uncertainties about the optimal treatment strategies of OSAJ patients will currently remain. Thus, prospective studies of OSAJ are needed but are only feasible in a multicenter study setting, conducted over a prolonged time period.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Malignant Neoplasms
Database:
LILACS
Main subject:
Bone Neoplasms
/
Osteosarcoma
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2019
Document type:
Article
Affiliation country:
Austria
/
Germany
Institution/Affiliation country:
Erlangen University Hospital/DE
/
Medical University Vienna/AT
/
Medical University of Vienna/AT