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Antifungal effects of Ziziphora tenuior, Lavandula angustifolia, Cuminum cyminum essential oils against clinical isolates of Candida albicans from women suffering from vulvovaginal candidiasis / Efecto antifungico de los aceites esenciales de Ziziphora tenuior, Lavandula angustifolia y Cuminum cyminum contra aislados clínicos de Candida albicans de mujeres que sufren de candidiasis vulvovaginal
Dolatabadi, Samaneh; Salari, Zahra; Mahboubi, Mohaddese.
Affiliation
  • Dolatabadi, Samaneh; Islamic Azad University. Neyshabur Branch. Department of Microbiology. Neyshabur. IR
  • Salari, Zahra; Islamic Azad University. Neyshabur Branch. Department of Microbiology. Neyshabur. IR
  • Mahboubi, Mohaddese; Tabib Daru Pharmaceutical Company. Research and Development. Medicinal Plants Research Department. Kashan. IR
Infectio ; 23(3): 222-226, jul.-sept. 2019. tab
Article in English | LILACS, COLNAL | ID: biblio-1002154
Responsible library: CO359.1
ABSTRACT
Candida sp. especially C. albicans is the main cause of candidiasis in women in reproductive ages. The prevalence of drug resistant C. albicans along with adverse effects of current treatments have encouraged the scientists to research on medicinal plant's essential oils. The aim of this study was to evaluate the potential effects of Ziziphora tenuior, Lavandula angustifolia, Cuminum cyminum essential oils against clinical isolates of C. albicans, which were isolated from women with vulvovaginal candidiasis. The anti-candidal effects of these commercial essential oils were screened against these clinical isolates (n=80) by disc diffusion and micro-broth dilution assays. The means of inhibition zone diameters, MIC and MFCs were reported for each essential oil. Also, the capability of fungal strain for biofilm formation in comparison with C. albicans ATCC 10231 were determined. The anti-biofilm effects of essential oils against 11 biofilm producing strains of C. albicans were determined. The results showed C. cyminum and Z. tenuior essential oils had the best anti-candidal effects, while the best biofilm killing effects was for L. angustifolia essential oil. C. cyminum and Z. tenuior essential oils can be formulated for more evaluations in preclinical and clinical studies.
RESUMEN
Candida sp., especialmente C. albicans, es la principal causa de candidiasis en mujeres en edad reproductiva. La aparición de resistencia a los antifungicos de C. albicans, junto con el riesgo de efectos adversos de los tratamientos actuales, ha llevado a los científicos a buscar alternativas en los aceites esenciales derivados de plantas. Los objetivos del estudio fueron evaluar los efectos potenciales de los aceites esenciales de Ziziphora tenuior, Lavandula angustifolia, Cuminum cyminum, contra aislados clínicos de C. albicans, obtenidos de mujeres con candidiasis vulvovaginal. Los efectos anti-Candida de estos aceites esenciales comerciales fueron probados contra estos aislados clínicos (n=80) por difusión en disco y ensayos de microdilución. Se obtuvo el promedio de diámetro de inhibición, MIC y MFCs para cada aceite esencial. También se comparó la capacidad de formación de biopelículas de 11 cepas de C. albicans de cada aislado frente a la cepa de referencia C. albicans ATCC 10231 y la capacidad de cada aceite esencial para evitar la formación de biopelículas. Los resultados muestran que los aceites esenciales de C. cyminum y Z. tenuior tuvieron la mejor actividad anti-Candida, mientras que los mejores efectos para destruir biopelículas se obtuvieron con los aceites esenciales de L. angustifolia. Los aceites esenciales de C. cyminum y Z. tenuior ameritan tener mayores evaluaciones preclínicas y clínicas.
Subject(s)


Full text: Available Collection: International databases Database: COLNAL / LILACS Main subject: Candida albicans / Candidiasis, Vulvovaginal / Oils, Volatile Type of study: Risk factors Limits: Adult / Female / Humans Language: English Journal: Infectio Journal subject: Communicable Diseases Year: 2019 Document type: Article Affiliation country: Iran Institution/Affiliation country: Islamic Azad University/IR / Tabib Daru Pharmaceutical Company/IR

Full text: Available Collection: International databases Database: COLNAL / LILACS Main subject: Candida albicans / Candidiasis, Vulvovaginal / Oils, Volatile Type of study: Risk factors Limits: Adult / Female / Humans Language: English Journal: Infectio Journal subject: Communicable Diseases Year: 2019 Document type: Article Affiliation country: Iran Institution/Affiliation country: Islamic Azad University/IR / Tabib Daru Pharmaceutical Company/IR
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