Large protein as a potential target for use in rabies diagnostics
Acta Virol
; 61(3): 280-288, Aug 28, 2017.
Article
in English
| Sec. Est. Saúde SP, SESSP-IPPROD, Sec. Est. Saúde SP
| ID: biblio-1017055
Responsible library:
BR84.1
Localization: BR84.1
ABSTRACT
Rabies is a zoonotic viral disease that remains a serious threat to public health worldwide. The rabies lyssavirus (RABV) genome encodes five structural proteins, multifunctional and significant for pathogenicity. The large protein (L) presents well-conserved genomic regions, which may be a good alternative to generate informative datasets for development of new methods for rabies diagnosis. This paper describes the development of a technique for the identification of L protein in several RABV strains from different hosts, demonstrating that MS-based proteomics is a potential method for antigen identification and a good alternative for rabies diagnosis.(AU) i
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
Sec. Est. Saúde SP
/
SESSP-IPPROD
Main subject:
Rabies
/
Viral Proteins
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta Virol
Year:
2017
Document type:
Article
Institution/Affiliation country:
Instituto Butantan/BR
/
Instituto Pasteur/BR