Your browser doesn't support javascript.
loading
Lack of evidence of seronegative infection in an endemic area of Chagas disease
Oliveira, Lea Campos de; Lee, Tzong-Hae; Ferreira, Ariela Mota; Bierrenbach, Ana Luiza; Basqueira, Marcela de Souza; Oliveira, Claudia di Lorenzo; Cardoso, Clareci Silva; Moreira, Carlos Henrique Valente; Oikawa, Márcio K; Ribeiro, Antônio Luiz P; Busch, Michael P; Sabino, Ester Cerdeira.
Affiliation
  • Oliveira, Lea Campos de; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Lee, Tzong-Hae; Blood Systems Research Institute. San Francisco. US
  • Ferreira, Ariela Mota; Universidade Estadual de Montes Claros. Montes Claros. BR
  • Bierrenbach, Ana Luiza; Hospital Sirio-Libanês. São Paulo. BR
  • Basqueira, Marcela de Souza; Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. São Paulo. BR
  • Oliveira, Claudia di Lorenzo; Universidade Federal de São João del Rei. São João del Rei. BR
  • Cardoso, Clareci Silva; Universidade Federal de São João del Rei. São João del Rei. BR
  • Moreira, Carlos Henrique Valente; Secretaria de Estado da Saúde. São Paulo. Instituto de Infectologia Emilio Ribas. São Paulo. BR
  • Oikawa, Márcio K; Universidade Federal do ABC. São Paulo. BR
  • Ribeiro, Antônio Luiz P; Universidade Federal de Minas Gerais. Belo Horizonte. BR
  • Busch, Michael P; Blood Systems Research Institute. San Francisco. BR
  • Sabino, Ester Cerdeira; Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. São Paulo. BR
Rev. Inst. Med. Trop. São Paulo (Online) ; 61: 11, Feb. 2019. ilus, tab
Article in English | Sec. Est. Saúde SP, SESSP-IIERPROD, Sec. Est. Saúde SP | ID: biblio-1020991
Responsible library: BR31.1
Localization: BR31.1; 2019_P-005
ABSTRACT
The diagnosis of Chagas disease is based on the detection of Trypanosoma cruzi (T. cruzi)-specific antibodies. Nonetheless, there is concern about the sensitivity of current serological assays due to reports of T. cruzi PCR positivity among seronegative individuals. The aim of this study was to evaluate if T. cruzi seronegative infections occur in endemic areas. We recruited 2,157 individuals that were identified as having Chagas disease in a public health system database of an endemic region in Brazil. All participants were interviewed and 2,091 had a sample collected for serological and PCR testing. From these, 149 (7.1%) had negative serological results. PCR was positive in 610 samples (31.4%) of the 1,942 seropositive samples but in none of the 149 samples from seronegative participants. True T. cruzi seronegative infections seem to be rare (95% CI 0-3.7) and should not be a concern for blood supply, which relies on antibody screening.
Subject(s)

Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: Available Collection: National databases / Brazil Health context: SDG3 - Health and Well-Being / Neglected Diseases Health problem: Target 3.3: End transmission of communicable diseases / Chagas Disease / Neglected Diseases Database: Sec. Est. Saúde SP / SESSP-IIERPROD Main subject: Brazil / Communicable Diseases / Chagas Disease Type of study: Prognostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Inst. Med. Trop. São Paulo (Online) Year: 2019 Document type: Article Institution/Affiliation country: Blood Systems Research Institute/BR / Blood Systems Research Institute/US / Hospital Sirio-Libanês/BR / Secretaria de Estado da Saúde. São Paulo/BR / Universidade Estadual de Montes Claros/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal de São João del Rei/BR / Universidade Federal do ABC/BR / Universidade de São Paulo/BR
Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: Available Collection: National databases / Brazil Health context: SDG3 - Health and Well-Being / Neglected Diseases Health problem: Target 3.3: End transmission of communicable diseases / Chagas Disease / Neglected Diseases Database: Sec. Est. Saúde SP / SESSP-IIERPROD Main subject: Brazil / Communicable Diseases / Chagas Disease Type of study: Prognostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Inst. Med. Trop. São Paulo (Online) Year: 2019 Document type: Article Institution/Affiliation country: Blood Systems Research Institute/BR / Blood Systems Research Institute/US / Hospital Sirio-Libanês/BR / Secretaria de Estado da Saúde. São Paulo/BR / Universidade Estadual de Montes Claros/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal de São João del Rei/BR / Universidade Federal do ABC/BR / Universidade de São Paulo/BR