Transmitted drug resistance among recently diagnosed adults and children in São Paulo, Brazil
AIDS Res Hum Retroviruses
; 31(12)2015.
Article
in English
| LILACS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO
| ID: biblio-1021437
Responsible library:
BR91.2
Localization: BR76.1
ABSTRACT
Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites in the São Paulo metropolitan area, collected from 2012 to 2014. The partial HIV-1 polymerase region was sequenced using Big Dye terminators at an ABI 3130 Genetic Analyzer. TDRM was defined according to the Stanford database calibrated population resistance (CPR v.6.0), but other drug resistance mutations (DRM) considered at the IAS list (IAS, 2014) and at the Stanford HIV Database Genotyping Resistance Interpretation (GRI-HIVdb) were also described. Out of 78% (170/217) of patients with information on the time of diagnosis, most (83%, 141/170) had been recently diagnosed, with the first positive HIV serology at a median of 58 days (IQR 18-184). Subtype B predominated (70%), followed by subtype F (10%), BF (7.5%), C (7.5%), and BC (5%). TDRMs were observed in 9.2% (20/217, CI 95% 5.9% to 13.6%), mostly (5.2%) to nonnucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral class. Among children and adolescents, only a single patient showed TDRMs. Additional non-CPR mutations were observed 11.5% (25/217) according to IAS or 4.6% (10/217) according to GRI-HIVdb. Overall, 23.5% (51/217) of the cases had one or more DRM identified. TDRM prevalence differed significantly among some sites. These trends deserve continuous and systematic surveillance, especially with the new policies of treatment as prevention being implemented in the country.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
AIDS
/
Antimicrobial Resistance
Database:
LILACS
/
Sec. Est. Saúde SP
/
SESSP-IALACERVO
/
SESSP-IALPROD
Main subject:
Brazil
/
Humans
/
Drug Resistance
/
HIV Infections
/
Child
/
Child, Preschool
/
Adolescent
/
HIV
/
Disease Transmission, Infectious
/
Adult
Type of study:
Diagnostic study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
AIDS Res Hum Retroviruses
Year:
2015
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Secretaria da Saúde do Estado de São Paulo/BR