Leishmaniasis-HIV coinfection: Current challenges
HIV AIDS (Auckl)
; 8: 147-156, Oct. 2016. tab, ilus
Article
in English
| Sec. Est. Saúde SP, SESSP-IIERPROD, Sec. Est. Saúde SP
| ID: biblio-1021866
Responsible library:
BR31.1
Localization: BR31.1; 2016_P-031
ABSTRACT
Leishmaniasis human immunodeficiency virus (HIV) coinfection can manifest itself as tegumentary or visceral leishmaniasis. Almost 35 countries have reported autochthonous coinfections. Visceral leishmaniasis is more frequently described. However, usual and unusual manifestations of tegumentary leishmaniasis have been reported mainly in the Americas, but the real prevalence of Leishmania infection in HIV-infected patients is not clear. Regarding the clinical manifestations, there are some reports showing unusual manifestations in visceral leishmaniasis and tegumentary leishmaniasis in HIV-infected patients; yet, the usual manifestations are more frequent. Leishmaniasis diagnosis relies on clinical methods, but serological tests are used to diagnose visceral leishmaniasis despite them having a low sensitivity to tegumentary leishmaniasis. The search for the parasite is used to diagnose both visceral leishmaniasis and tegumentary leishmaniasis. Nevertheless, in HIV-infected patients, the sensitivity of serology is very low. Drugs available to treat leishmaniasis are more restricted and cause severe side effects. Furthermore, in HIV-infected patients, these side effects are more prominent and relapses and lethality are more recurrent. In this article, we discuss the current challenges of tegumentary leishmaniasis and visceral leishmaniasisHIV infection, focusing mainly on the clinical manifestations, diagnosis, and treatment of leishmaniasis
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IIERPROD
Main subject:
Leishmaniasis
/
HIV Infections
/
Coinfection
Type of study:
Risk factors
Limits:
Humans
Language:
English
Journal:
HIV AIDS (Auckl)
Year:
2016
Document type:
Article
Institution/Affiliation country:
SESAP/BR
/
Secretaria de Estado da Saúde. São Paulo/BR
/
Universidade de São Paulo/BR