Tuberculosis in HIV-infected children in Europe, Thailand and Brazil: Paediatric TB-HIV EuroCoord study
Int. j. tuberc. lung dis
; 20(11): 1448-1456, Nov. 2016. ilus, tab
Article
in English
| Sec. Est. Saúde SP, SESSP-IIERPROD, Sec. Est. Saúde SP
| ID: biblio-1021996
Responsible library:
BR31.1
Localization: BR31.1; 2016_P-059
ABSTRACT
SETTING:
Centres participating in the Paediatric European Network for Treatment of AIDS (PENTA), including Thailand and Brazil.OBJECTIVE:
To describe the incidence, presentation, treatment and treatment outcomes of tuberculosis (TB) in human immunodeficiency virus (HIV) infected children.DESIGN:
Observational study of TB diagnosed in HIV-infected children in 2011-2013.RESULTS:
Of 4265 children aged <16 years, 127 (3%) were diagnosed with TB 6 (5%) in Western Europe, 80 (63%) in Eastern Europe, 27 (21%) in Thailand and 14 (11%) in Brazil, with estimated TB incidence rates of respectively 239, 982, 1633 and 2551 per 100 000 person-years (py). The majority (94%) had acquired HIV perinatally. The median age at TB diagnosis was 6.8 years (interquartile range 3.0-11.5). Over half (52%) had advanced/severe World Health Organization stage immunodeficiency; 67 (53%) were not on antiretroviral therapy (ART) at TB diagnosis. Preventive anti-tuberculosis treatment was given to 23% (n = 23) of 102 children diagnosed with HIV before TB. Eleven children had unfavourable TBoutcomes:
4 died, 5 did not complete treatment, 1 had recurrent TB and 1 had an unknown outcome. In univariable analysis, previous diagnosis of acquired immune-deficiency syndrome, not being virologically suppressed on ART at TB diagnosis and region (Brazil) were significantly associated with unfavourable TB outcomes.CONCLUSION:
Most TB cases were from countries with high TB prevalence. The majority (91%) had favourable outcomes. Universal ART and TB prophylaxis may reduce missed opportunities for TB prevention
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.8 Achieve universal access to health
/
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Tuberculosis
Database:
Sec. Est. Saúde SP
/
SESSP-IIERPROD
Main subject:
Tuberculosis
/
Child
/
AIDS-Related Opportunistic Infections
Type of study:
Observational study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Int. j. tuberc. lung dis
Year:
2016
Document type:
Article
Institution/Affiliation country:
Donetsk Regional Centre for Prevention and Control of AIDS/UA
/
Institut de Recherche pour le Developpement Unites Mixtes Internationales 174/TH
/
Irkutsk Regional Centre for Prevention and Control of AIDS and Infectious Diseases/UA
/
Kryvyi Rih City Centre for Prevention and Control of AIDS/UA
/
Latvian Centre of Infectious Diseases/LV
/
Marioupol City Centre for Prevention and Control of AIDS/UA
/
Nakornping Hospital/TH
/
Perinatal Prevention of AIDS Initiative/UA
/
Republican Clinical Hospital of Infectious Diseases/RU
/
Secretaria de Estado da Saúde. São Paulo/BR