Non-polarized cytokine profile of a long-term non-progressor HIV infected patient
Braz. j. infect. dis
; 22(2): 142-145, Mar.-Apr. 2018. tab
Article
in English
| LILACS
| ID: biblio-1039213
Responsible library:
BR1.1
ABSTRACT
ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
LILACS
Main subject:
HIV Infections
/
Cytokines
/
HIV-1
/
HIV Long-Term Survivors
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Departamento Municipal de Saúde/BR
/
Universidade Federal do Mato Grosso do Sul/BR