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There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment
Silva, Paula Carolina Valença; Silva, Aline Vieira da; Silva, Taysa Nascimento; Vasconcelos, Letícia Moura de; Gomes, Adriana Vieira; Coêlho, Maria Rosângela Cunha Duarte; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho.
Affiliation
  • Silva, Paula Carolina Valença; Universidade Federal de Pernambuco. Centro Acadêmico de Vitória. Vitória de Santo Antão. BR
  • Silva, Aline Vieira da; Universidade Federal de Pernambuco. Centro Acadêmico de Vitória. Vitória de Santo Antão. BR
  • Silva, Taysa Nascimento; Universidade Federal de Pernambuco. Centro Acadêmico de Vitória. Vitória de Santo Antão. BR
  • Vasconcelos, Letícia Moura de; Universidade Federal de Pernambuco. Centro Acadêmico de Vitória. Vitória de Santo Antão. BR
  • Gomes, Adriana Vieira; Universidade de Pernambuco. Centro de Oncohematologia Pediátrica. Laboratório de Biologia Molecular. Recife. BR
  • Coêlho, Maria Rosângela Cunha Duarte; Universidade Federal de Pernambuco. Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami. Recife. BR
  • Muniz, Maria Tereza Cartaxo; Universidade de Pernambuco. Centro de Oncohematologia Pediátrica. Laboratório de Biologia Molecular. Recife. BR
  • Domingues, Ana Lúcia Coutinho; Universidade Federal de Pernambuco. Departamento de Medicina Clínica. Recife. BR
Rev. Soc. Bras. Med. Trop ; 49(6): 781-785, Dec. 2016. tab
Article in English | LILACS | ID: biblio-1041384
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.

METHODS:

This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.

RESULTS:

There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.

CONCLUSIONS:

There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.
Subject(s)

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Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Helminthiasis / Neglected Diseases / Schistosomiasis / Zoonoses Database: LILACS Main subject: Schistosomiasis mansoni / Interleukin-10 / Peritoneal Fibrosis Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2016 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR / Universidade de Pernambuco/BR
Fulltext
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Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Helminthiasis / Neglected Diseases / Schistosomiasis / Zoonoses Database: LILACS Main subject: Schistosomiasis mansoni / Interleukin-10 / Peritoneal Fibrosis Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2016 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR / Universidade de Pernambuco/BR