Poly(3-hydroxybutyrate) graft copolymer dense membranes for human mesenchymal stem cell growth
Electron. j. biotechnol
; 34: 59-66, july. 2018. graf, tab, ilus
Article
in English
| LILACS
| ID: biblio-1047365
Responsible library:
CL1.1
ABSTRACT
Background:
The use of novel materials as an artificial extracellular matrix for stem cell growth is a current strategy of increasing interest for regenerative medicine. Here, we prepare thermal-remolded membrane scaffolds from poly(3-hydroxybutyrate) grafted with 2-amino-ethyl methacrylate hydrochloride. However, it is unclear whether these membranes are useful for tissue engineering.Results:
The mechanical properties, tribology, and morphology of the dense membranes were assessed. The results show that tensile strain at break and roughness of the compressed membrane decrease with increasing graft degree. Moreover, graft copolymer membranes showed lower resistance to scratching, greater degree of swelling and higher brittleness than un-grafted P(3HB) films. Thus, it effectively supports the growth of dermal fibroblast, as demonstrated by epifluorescence microscopy.Conclusions:
It is concluded that the developed membrane can be properly used in is the restoration of skin tissue. How to cite González-Torres M, Sánchez-Sánchez R, Solís-Rosales SG, et al. Poly(3-hydroxybutyrate) graft copolymer dense membranes for human mesenchymal stem cell growth.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Mesenchymal Stem Cells
/
Membranes, Artificial
Language:
English
Journal:
Electron. j. biotechnol
Journal subject:
Biotechnology
Year:
2018
Document type:
Article
Affiliation country:
Mexico
/
United States
Institution/Affiliation country:
Benemérita Universidad Autónoma de Puebla/MX
/
Centro de Investigación en Química Aplicada/MX
/
Instituto Nacional de Rehabilitación "Luís Guillermo Ibarra Ibarra"/MX
/
Tecnológico de Monterrey/MX
/
University of North Texas/US