Ultrastructural effects of diabetes in the right atrium cardiomyocytes of elderly Wistar rats
Cardiovasc. pathol
; (45)nov., 2019. tab., graf., ilus.
Article
in English
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1049448
Responsible library:
BR79.1
Localization: BR79.1
ABSTRACT
The present study aimed to evaluate the effects of diabetes on quantitative parameters of right atrial cardiomyocytes of elderly rats. Wistar rats (14-mo of age) were divided into two groups streptozotocin-diabetic rats (DG); and control rats (CG). The groups were sacrificed at 16 months. Ultrafine sections of the right atrium were analyzed by electron microscopy. In elderly diabetic animals, histograms of the frequency distribution of natriuretic peptides according to their size showed increased number of small and medium peptides in relation to large peptides, which increased its numerical density leading to a decrease in the mean diameter of both natriuretic peptides. However, elderly diabetic animals remained normotensive. No significant difference was observed between the groups for the volume density of mitochondria, endoplasmic reticulum and Golgi apparatus. In conclusion, elderly diabetic rats showed increased functional activity of atrial cardiomyocytes with greater production of natriuretic peptides in association with a quantitative maintenance of cytoplasmic components. (AU)
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Aging
/
Microscopy, Electron
/
Streptozocin
Language:
English
Journal:
Cardiovasc. pathol
Year:
2019
Document type:
Article
Institution/Affiliation country:
Institute of Biomedical Sciences of University of São Paulo/BR
/
São Judas Tadeu University/BR
/
Uninove/BR
/
University of São Paulo Medical School/BR