New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
Acta cir. bras
; 34(12): e201901201, 2019. graf
Article
in English
| LILACS
| ID: biblio-1054690
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group) Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Organometallic Compounds
/
Ruthenium
/
Anti-Inflammatory Agents, Non-Steroidal
/
Nitric Oxide Donors
/
Meloxicam
/
Kidney Diseases
Type of study:
Evaluation study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro Universitário Christus/BR
/
UFC/BR
/
UNICHRISTUS/BR
/
Universidade Federal do Ceará/BR