In vivo antileishmanial activity of Annona mucosa extracts
Rev. Soc. Bras. Med. Trop
; 53: e20190139, 2020. graf
Article
in English
| LILACS
| ID: biblio-1057288
Responsible library:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem.METHODS:
Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa.RESULTS:
Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels.CONCLUSIONS:
Extracts of A. mucosa are promising sources of novel antileishmanial compounds.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
LILACS
Main subject:
Plant Extracts
/
Leishmaniasis, Cutaneous
/
Annona
/
Leishmania
/
Antiprotozoal Agents
Limits:
Animals
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2020
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Santa Cruz/BR
/
Universidade Federal do Amazonas/BR