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Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio
Ururahy, MA; Souza, KSC; Oliveira, YM; Loureiro, MB; Silva, HP; Freire-Neto, FP; Bezerra, JF; Luchessi, AD; Doi, SQ; Hirata, RD; Almeida, Md; Arrais, RF; Hirata, MH; Rezende, AA.
Affiliation
  • Ururahy, MA; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Souza, KSC; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Oliveira, YM; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Loureiro, MB; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Silva, HP; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Freire-Neto, FP; Department of Biochemistry, Federal University of Rio Grande do Norte. Natal. BR
  • Bezerra, JF; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Luchessi, AD; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Doi, SQ; Department of Medicine, Uniformed Services University of the Health Sciences. Bethesda. US
  • Hirata, RD; Department of Clinical and Toxicological Analyses, University of São Paulo. São Paulo. BR
  • Almeida, Md; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
  • Arrais, RF; Department of Pediatrics, Federal University of Rio Grande do Norte. Natal. BR
  • Hirata, MH; Department of Clinical and Toxicological Analyses, University of São Paulo. São Paulo. BR
  • Rezende, AA; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte. Natal. BR
Diabetes Metab Res Rev ; 31(5): 500-506, 2015.
Article in English | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1062375
Responsible library: BR79.1
Localization: BR79.1
ABSTRACT

BACKGROUND:

Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been considered as key factors in type 1 diabetes mellitus (T1DM) and diabetic nephropathy, thus, our aim was to investigate the association of IL6-174G>C (rs1800795) and -634C>G (rs1800796) polymorphisms with T1DM susceptibility and diabetic nephropathy.

METHODS:

These polymorphisms were analyzed in 144 children and adolescents with T1DM and 173 normoglycemic control subjects. Glycemic control, laboratory parameters of kidney function and serum lipids were evaluated. By studying only T1DM patients, we evaluated the polymorphisms associated with relevant biochemical parameters in various genetic models.

RESULTS:

Type 1 diabetes mellitus patients showed poor glycemic control and albumin-to-creatinine ratio, total cholesterol and LDL-cholesterol levels increased when compared with normoglycemic subjects (p G polymorphism...
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Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Cytokines / Diabetes Mellitus, Type 1 Type of study: Prognostic study / Risk factors Language: English Journal: Diabetes Metab Res Rev Year: 2015 Document type: Article Institution/Affiliation country: Department of Biochemistry, Federal University of Rio Grande do Norte/BR / Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte/BR / Department of Clinical and Toxicological Analyses, University of São Paulo/BR / Department of Medicine, Uniformed Services University of the Health Sciences/US / Department of Pediatrics, Federal University of Rio Grande do Norte/BR
Search on Google
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Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Cytokines / Diabetes Mellitus, Type 1 Type of study: Prognostic study / Risk factors Language: English Journal: Diabetes Metab Res Rev Year: 2015 Document type: Article Institution/Affiliation country: Department of Biochemistry, Federal University of Rio Grande do Norte/BR / Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte/BR / Department of Clinical and Toxicological Analyses, University of São Paulo/BR / Department of Medicine, Uniformed Services University of the Health Sciences/US / Department of Pediatrics, Federal University of Rio Grande do Norte/BR