CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction
J tromb Thrombolysis
; 36: 332-340, 20130000. tab
Article
in English
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1063721
Responsible library:
BR79.1
Localization: BR79.1
ABSTRACT
Abstract This study investigated the relationship of polymorphismsin genes encoding CD14, IL-6 and TLR4 withmetabolic, inflammatory and endothelial markers in youngadults with acute myocardial infarction (AMI). Glucose,lipids, nitrate and inflammatory markers, flow mediatedvasodilatation (FMV) and flow mediated by nitrate (FMN)were evaluated in 102 AMI and 108 non-AMI (controlgroup) young individuals (% years). CD14 -260C[T(rs2569190), IL6 -174G[C (rs1800795) and TLR4c.896A[G (rs4986790) and TLR4 c.1196C[T (rs4986791)polymorphisms were analyzed by PCRRFLP. Minor allelefrequencies of CD14, IL6 and TLR4 polymorphisms weresimilar between AMI and control groups (p[0.05). In AMIgroup, individuals carrying IL6 -174CC genotype hadhigher serum triglycerides, VLDL cholesterol and glucosecompared to the IL6 -174GG/GC genotype carriers(p84 2013-11-12
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Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Polymorphism, Genetic
/
Lipopolysaccharide Receptors
/
Myocardial Infarction
Type of study:
Risk factors
Language:
English
Journal:
J tromb Thrombolysis
Year:
2013
Document type:
Article
Institution/Affiliation country:
Department of Clinical Analysis and Toxicology, Faculdade deCiencias Farmaceuticas, School of Pharmaceutical Sciences/BR
/
Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, University of Sao Paulo/BR
/
Institute Dante Pazzanese of Cardiology/BR