LEP 3'HVR is associated with obesity and leptin levels in Brazilian individuals
Mol Genet Metabol
; 89(04): 374-380, 12 2006.
Article
in English
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1064781
Responsible library:
BR79.1
Localization: BR79.1
ABSTRACT
Leptin plays an important role in satiety signaling and is related to obesity. Variants of leptin gene (LEP) have been associated to diVerences in plasma leptin levels and obesity-related phenotypes. The purpose of this study was to evaluate the association of LEP 3 HVR and leptin concentrations and obesity-related traits in our population. Anthropometrics and systolic/diastolic pressure were measured in 210 unrelated Brazilian individuals. Blood samples were collected for quantiWcation of leptin, glucose and lipids and DNA extraction. LEP 3 HVR polymorphic region was ampliWed by PCR and fragments were analyzed by polyacrylamide gel electrophoresis. Obesity was associated with hypertension, hyperglycemia, obesity-related traits, plasma leptin and serum lipids (p < 0.05). The frequency of LEP 3 HVR class I alleles (I/I+ I/II genotypes) was higher in obese (pD0.043) than in non-obese individuals. Multivariate logistic regression showed that the risk for obesity is nine times higher in hypertensive individuals and two times higher in class I alleles carriers. The presence of class I alleles was associated with increased BMI and WC. Plasma leptin was related to class I alleles in women (p <0.05). No association was found between LEP 3 HVR and hypertension or risk factors for CAD in our sample. Our results suggest that LEP 3 HVR is an important predictor for obesity-related traits and leptin plasma levels.
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Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Leptin
/
Arterial Pressure
/
Obesity
Type of study:
Prognostic study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mol Genet Metabol
Year:
2006
Document type:
Article
Institution/Affiliation country:
Dante Pazzanese Institute of Cardiology/BR
/
Department of Clinical and Toxicological Analysis/BR