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Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients
Salgado, Patricia C; Genvigir, Fabiana Dv; Felipe, Claudia R; Tedesco-Silva, Helio Jr; Medina-Pestana, Jose O; Doi, Sonia Q; Hirata, Mario H; Hirata, Rosario Dc.
Affiliation
  • Salgado, Patricia C; University of São Paulo. São Paulo. BR
  • Genvigir, Fabiana Dv; University of São Paulo. São Paulo. BR
  • Felipe, Claudia R; Federal University of Sao Paulo. São Paulo. BR
  • Tedesco-Silva, Helio Jr; Federal University of Sao Paulo. São Paulo. BR
  • Medina-Pestana, Jose O; Federal University of Sao Paulo. Hospital do Rim. São Paulo. BR
  • Doi, Sonia Q; Uniformed Services University of the Health Sciences. Bethesda. US
  • Hirata, Mario H; University of São Paulo. São Paulo. BR
  • Hirata, Rosario Dc; University of São Paulo. São Paulo. BR
Pharmgenomics Pers Med ; 10: 101-106, 2017. tab
Article in English | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1065491
Responsible library: BR79.1
Localization: BR79.1
ABSTRACT

BACKGROUND:

The effects of genetic variants related to the pharmacodynamic mechanisms of immunosuppressive drugs on their therapeutic efficacy and safety have been poorly explored. This study was performed to investigate the influence of the PPP3CA c.249G>A variant on the clinical outcomes of kidney transplant recipients.PATIENTS AND

METHODS:

A total of 148 Brazilian patients received tacrolimus (TAC)-based immunosuppressive therapy for 90 days post-kidney transplantation. The PPP3CA rs3730251 (c.249G>A) polymorphism was determined by real-time polymerase chain reaction. Single-nucleotide polymorphism (SNP) data for CYP3A5 rs776746 (CYP3A5*3C; g.6986A>G) were used to eliminate the confounding effects of this variant.
Subject(s)

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Full text: Available Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Kidney Transplantation / Tacrolimus Type of study: Risk factors Language: English Journal: Pharmgenomics Pers Med Year: 2017 Document type: Article Institution/Affiliation country: Federal University of Sao Paulo/BR / Uniformed Services University of the Health Sciences/US / University of São Paulo/BR
Fulltext
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Full text: Available Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Kidney Transplantation / Tacrolimus Type of study: Risk factors Language: English Journal: Pharmgenomics Pers Med Year: 2017 Document type: Article Institution/Affiliation country: Federal University of Sao Paulo/BR / Uniformed Services University of the Health Sciences/US / University of São Paulo/BR