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Constitutive expression of genes encoding notch receptors and ligandsin developing lymphocytes, nTreg cells and dendritic cells in the human thymus
Souza, Luciana Bento de; Victor, Jefferson R; Souza, Luiz C Bento de; Santos, Magaly Arrais; Santos, Andréia C Rangel; Costa, Érica Pereira; Fernandes, Elaine Raniero; Duarte, Maria I Seixas; Oliveira Filho, João B; Duarte, Alberto J Silva.
Affiliation
  • Souza, Luciana Bento de; Laboratory of Medical Investigation in Dermatology and Immunodeficiencies. São Paulo. BR
  • Victor, Jefferson R; Laboratory of Medical Investigation in Dermatology and Immunodeficiencies. São Paulo. BR
  • Souza, Luiz C Bento de; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Santos, Magaly Arrais; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Santos, Andréia C Rangel; Laboratory of Medical Investigation in Dermatology and Immunodeficiencies. São Paulo. BR
  • Costa, Érica Pereira; Laboratory of Medical Investigation in Dermatology and Immunodeficiencies. São Paulo. BR
  • Fernandes, Elaine Raniero; Institute of Integrative Medicine Professor Fernando Figueira. Recife. BR
  • Duarte, Maria I Seixas; Laboratory of Pathology of Transmissible Diseases, School of Medicine. São Paulo. BR
  • Oliveira Filho, João B; Institute of Integrative Medicine Professor Fernando Figueira. Recife. BR
  • Duarte, Alberto J Silva; Hospital do Coração. São Paulo. BR
Results Immunol ; 6(dx.doi.org/10.1016/j.rinim.2016.04.001): 15-20, 2016. graf
Article in English | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1066242
Responsible library: BR79.1
Localization: BR79.1
ABSTRACT
The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2)constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus...
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Full text: Available Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Thymus Gland / Genes Language: English Journal: Results Immunol Year: 2016 Document type: Article Institution/Affiliation country: Hospital do Coração/BR / Institute of Integrative Medicine Professor Fernando Figueira/BR / Instituto Dante Pazzanese de Cardiologia/BR / Laboratory of Medical Investigation in Dermatology and Immunodeficiencies/BR / Laboratory of Pathology of Transmissible Diseases, School of Medicine/BR
Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: Available Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Thymus Gland / Genes Language: English Journal: Results Immunol Year: 2016 Document type: Article Institution/Affiliation country: Hospital do Coração/BR / Institute of Integrative Medicine Professor Fernando Figueira/BR / Instituto Dante Pazzanese de Cardiologia/BR / Laboratory of Medical Investigation in Dermatology and Immunodeficiencies/BR / Laboratory of Pathology of Transmissible Diseases, School of Medicine/BR