Human migration and the spread of malaria parasites to the New World
Scientific Reports
; 8(1993): 1-13, Jan, 2018. tab, ilus, map
Article
in English
| Sec. Est. Saúde SP, SESSP-SUCENPROD, Sec. Est. Saúde SP
| ID: biblio-1067911
Responsible library:
BR93.2
Localization: BR93.2
ABSTRACT
We examined the mitogenomes of a large global collection of human malaria parasites to explore how and when Plasmodium falciparum and P. vivax entered the Americas. We found evidence of a significant contribution of African and South Asian lineages to present-day New World malaria parasites with additional P. vivax lineages appearing to originate from Melanesia that were putatively carried by the Australasian peoples who contributed genes to Native Americans. Importantly, mitochondrial lineages of the P. vivax-like species P. simium are shared by platyrrhine monkeys and humans in the Atlantic Forest ecosystem, but not across the Amazon, which most likely resulted from one or a few recent human-to-monkey transfers. While enslaved Africans were likely the main carriers of P.falciparum mitochondrial lineages into the Americas after the conquest, additional parasites carried by Australasian peoples in pre-Columbian times may have contributed to the extensive diversity of extant local populations of P. vivax...
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Malaria
/
Neglected Diseases
Database:
Sec. Est. Saúde SP
/
SESSP-SUCENPROD
Main subject:
Plasmodium falciparum
/
Plasmodium vivax
/
Malaria
Limits:
Animals
/
Humans
Language:
English
Journal:
Scientific Reports
Year:
2018
Document type:
Article
Institution/Affiliation country:
Federal University of Minas Gerais/BR
/
State Secretary of Health/BR
/
University of São Paulo/BR