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Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine
Menezes, Carla M. S.; Kirchgatter, Karin; Di Santi, Silvia Maria; Savalli, C.; Monteiro, Fabíola G.; Paula, Gilberto A..
Affiliation
  • Menezes, Carla M. S.; s.af
  • Kirchgatter, Karin; s.af
  • Di Santi, Silvia Maria; s.af
  • Savalli, C.; s.af
  • Monteiro, Fabíola G.; s.af
  • Paula, Gilberto A.; s.af
Trans.Royal Trop.Med.Hyg ; 91: 697-700, may.-1997. tab, graf
Article in English | Sec. Est. Saúde SP, SESSP-SUCENPROD, Sec. Est. Saúde SP | ID: biblio-1068298
Responsible library: BR93.2
Localization: BR93.2
ABSTRACT
Based on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests (IC50 = 44.26 and 46.53 ug/L for desipramine L for imipramine), but no reversal of resistance when added to cultures together with chloroquine.
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Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-SUCENPROD Main subject: Plasmodium falciparum / Chloroquine / Desipramine Limits: Female / Humans / Male Language: English Journal: Trans.Royal Trop.Med.Hyg Year: 1997 Document type: Article
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Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-SUCENPROD Main subject: Plasmodium falciparum / Chloroquine / Desipramine Limits: Female / Humans / Male Language: English Journal: Trans.Royal Trop.Med.Hyg Year: 1997 Document type: Article