Molecular epidemiology of rabies virus strains isolated from wild canids in Northeastern Brazil
Virus Research
; 120(1-2): 113-120, sept. 2006. ilus, map, tab
Article
in English
| Sec. Est. Saúde SP, SESSP-IPPROD, Sec. Est. Saúde SP
| ID: biblio-1068418
Responsible library:
BR84.1
Localization: BR84.1
ABSTRACT
Rabies in wild canids in Northeastern Brazil is frequent and has been reported for some time, with episodes of rabies transmission from these animals to humans also reported. In this study, we analyzed the antigenic and genetic profiles of the rabies virus nucleoprotein gene, isolated from 20 samples taken from domestic animals and wild canids located in the Northeastern region of Brazil. All viruses isolated from domestic animals (dogs and cats) belonged to the antigenic variant 2 (AgV2). Among the wild animal samples, only four were AgV2, and nine showed a divergent antigenic profile. Phylogenetic analysis revealed two Brazilian clusters. Cluster 1 (Brazilian domestic carnivore-related strains) showed two subclusters, called 1A and 1B, and cluster 2 (Brazilian wild canid-related strains) also showed two subclusters, called 2A and 2B. The majority of the samples with divergent antigenic strains segregated into subcluster 2A. The intracluster identity of cluster 1 was 95.6% and that of cluster 2, 92.4%. When clusters 1 and 2 were compared, an identity of 88.6% was found. The genetic analysis of wild canid samples performed in this study indicates that there are two distinct rabies cycles among canids in Brazil, one represented by domestic canids and the other by wild canids. This study shows that the virus samples isolated in Northeastern Brazil are region and species-specific.
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
Sec. Est. Saúde SP
/
SESSP-IPPROD
Main subject:
Phylogeny
/
Rabies virus
/
Molecular Epidemiology
Type of study:
Screening study
Limits:
Animals
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Virus Research
Year:
2006
Document type:
Article
Institution/Affiliation country:
Fundação Municipal de Saúde/BR
/
Laboratorio de Apoio Animal/BR
/
Lacen Prof. Gonçalo Muniz/BR
/
Ministerio da Saúde/BR
/
Secretaria de Estado da Saúde de São Paulo/BR