Evaluation of TSH Levels in the Program of Congenital Hypothyroidism Newborn Screening in a Pilot Study of Preterm Newborns in Bogotá, Colombia
J. inborn errors metab. screen
; 3: e150003, 2015. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1090866
Responsible library:
BR1.1
ABSTRACT
Abstract Introduction:
Preterm infants (<37 weeks of gestation) have low levels of thyroid hormones due to multiple factors.Objective:
To evaluate levels of thyroid-stimulation hormone (TSH) in the program congenital hypothyroidism (CH) newborn screening in a sample of preterm infants in the city of Bogotá, Colombia.Methods:
The Secretaría de Salud Distrital screening protocol for CH (blood sample is collected from the umbilical cord in all the newborns) remeasured the serum TSH and heel TSH when preterm infants completed 37 weeks of gestation.Results:
A total of 59 preterm neonates were rescreened, of which 2 neonates had elevated levels of TSH and 1 neonate had transient hypothyroxinemia. The Kolmogorov-Smirnov 2-sample/bilateral statistical test was used to compare the neonatal TSH levels of preterm and full-term newborns, which do not follow the same distribution.Conclusion:
In our pilot study, 2 of the rescreened infants presented high levels of TSH and 1 had transient hyperthyrotropinemia, suggesting the need for rescreening of preterm infants. Additionally, a larger study should be performed to determine the screening cutoff values for preterm newborns.
Full text:
Available
Collection:
International databases
Database:
LILACS
Type of study:
Diagnostic study
/
Evaluation study
/
Screening study
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
J. inborn errors metab. screen
Journal subject:
Medicina Cl¡nica
/
Patologia
Year:
2015
Document type:
Article
Affiliation country:
Colombia
Institution/Affiliation country:
Pontificia Universidad Javeriana/CO
/
Secretaría de Salud de Bogotá/CO