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Tocilizumab for juvenile idiopathic arthritis: a single-center case series
Yazılıtaş, Fatma; Özdel, Semanur; Şimşek, Doğan; Aydoğ, Özlem; Çakıcı, Evrim Kargın; Can, Gökçe Gür; Güngör, Tülin; Bülbül, Mehmet.
Affiliation
  • Yazılıtaş, Fatma; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Nephrology. Ankara. TR
  • Özdel, Semanur; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Rheumatology. Ankara. TR
  • Şimşek, Doğan; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Rheumatology. Ankara. TR
  • Aydoğ, Özlem; Ondokuz Mayis Üniversitesi Tip Fakültesi. Department of Pediatric Nephrology and Rheumatology. Samsun. TR
  • Çakıcı, Evrim Kargın; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Nephrology. Ankara. TR
  • Can, Gökçe Gür; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Nephrology. Ankara. TR
  • Güngör, Tülin; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Nephrology. Ankara. TR
  • Bülbül, Mehmet; Sağlik Bilimleri Üniversitesi. Dr. Sami Ulus Kadin Doğum Çocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Hastanesi. Department of Pediatric Nephrology and Rheumatology. Ankara. TR
São Paulo med. j ; São Paulo med. j;137(6): 517-522, Nov.-Dec. 2019. tab
Article in En | LILACS | ID: biblio-1094529
Responsible library: BR1.1
ABSTRACT
ABSTRACT

BACKGROUND:

Juvenile idiopathic arthritis (JIA) is the commonest chronic rheumatic disease among children. When not treated effectively, JIA can lead to functional disability, due to joint damage, along with long-term morbidities.

OBJECTIVES:

To describe the use of tocilizumab therapy for 11 patients with polyarticular JIA (pJIA) and systemic JIA (sJIA) who presented inadequate response or were refractory to disease-modifying anti-rheumatic drugs (DMARDs) and/or other biological therapies; and to evaluate its benefits, safety and tolerability. DESIGN AND

SETTING:

Observational retrospective case series at a tertiary-level training and research hospital.

METHODS:

We reviewed the medical records of 11 consecutive patients with JIA who received tocilizumab (anti-IL-6) therapy in our pediatric nephrology and rheumatology outpatient clinic. We analyzed their demographic data, clinical and laboratory findings, treatment response and adverse reactions. We determined the efficacy of tocilizumab treatment using the American College of Rheumatology (ACR) pediatric (Pedi) response criteria, including ACR Pedi 30, 50, 70 and 90 scores. We used the Wilcoxon test to compare measurements before and after treatment.

RESULTS:

Tocilizumab was given to seven patients with sJIA and four with pJIA (one of the pJIA patients was rheumatoid factor-positive). In most patients, we observed improvement of symptoms, absence of articular and extra-articular inflammation and continued inactive disease. ACR Pedi 30, 50 and 70 scores were achieved by 90.9% of the patients. Five patients showed minor side effects, possibly due to use of tocilizumab.

CONCLUSIONS:

Tocilizumab therapy should be considered for treating patients with diagnoses of pJIA or sJIA who are resistant to non-biological DMARDs and/or other biological therapies.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Arthritis, Juvenile / Antirheumatic Agents / Antibodies, Monoclonal, Humanized Type of study: Observational_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / MEDICINA / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2019 Document type: Article Affiliation country: Turkey Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Arthritis, Juvenile / Antirheumatic Agents / Antibodies, Monoclonal, Humanized Type of study: Observational_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / MEDICINA / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2019 Document type: Article Affiliation country: Turkey Country of publication: Brazil