ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant Gram-negative bacteria carriers
Clin. microbiol. infect
; 25(7): [1-11], Jan. 29, 2019.
Article
in English
| BIGG - GRADE guidelines
| ID: biblio-1094956
Responsible library:
BR1.1
ABSTRACT
The aim of these guidelines is to provide recommendations for decolonizing regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all settings. Methods:
These evidence-based guidelines were produced after a systematic review of published studies on decolonization interventions targeting the following MDR-GNB third-generation cephalosporinresistant Enterobacteriaceae (3GCephRE), carbapenem-resistant Enterobacteriaceae (CRE), aminoglycoside-resistant Enterobacteriaceae (AGRE), fluoroquinolone-resistant Enterobacteriaceae (FQRE), extremely drug-resistant Pseudomonas aeruginosa (XDRPA), carbapenem-resistant Acinetobacter baumannii (CRAB), cotrimoxazole-resistant Stenotrophomonas maltophilia (CRSM), colistin-resistant Gram-negative organisms (CoRGNB), and pan-drug-resistant Gram-negative organisms (PDRGNB). The recommendations are grouped by MDR-GNB species. Faecal microbiota transplantation has been discussed separately. Four types of outcomes were evaluated for each target MDR-GNB(a) microbiological outcomes (carriage and eradication rates) at treatment end and at specific post-treatment time-points; (b) clinical outcomes (attributable and all-cause mortality and infection incidence) at the same timepoints and length of hospital stay; (c) epidemiological outcomes (acquisition incidence, transmission and outbreaks); and (d) adverse events of decolonization (including resistance development). The level of evidence for and strength of each recommendation were defined according to the GRADE approach. Consensus of a multidisciplinary expert panel was reached through a nominal-group technique for the final list of recommendations.
Full text:
Available
Collection:
Tematic databases
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
BIGG - GRADE guidelines
Main subject:
Cephalosporins
/
Gram-Negative Bacterial Infections
/
Fluoroquinolones
/
Enterobacteriaceae Infections
/
Aminoglycosides
Type of study:
Practice guideline
Language:
English
Journal:
Clin. microbiol. infect
Year:
2019
Document type:
Article