CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico
An. bras. dermatol
; 95(3): 283-288, May-June 2020. tab
Article
in English
| LILACS, Coleciona SUS
| ID: biblio-1130886
Responsible library:
BR1.1
ABSTRACT
Abstract Background:
Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial.Objective:
The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population.Methods:
We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP.Results:
No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05). Studylimitations:
Small sample size of patients and the data were obtained from Northeast Mexico population.Conclusion:
The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
LILACS
/
Coleciona SUS
Main subject:
Genetic Variation
/
Alopecia Areata
/
CTLA-4 Antigen
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
English
Journal:
An. bras. dermatol
Year:
2020
Document type:
Article
Institution/Affiliation country:
Universidad Autónoma de Coahuila/MX
/
Universidad Autónoma de Nuevo León/MX