Spitz nevus and infliximab: association or coincidence?
An. bras. dermatol
; 95(5): 615-618, Sept.-Oct. 2020. graf
Article
in English
| LILACS, Coleciona SUS
| ID: biblio-1130930
Responsible library:
BR1.1
ABSTRACT
Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression seems to play a key role in this phenomenon. Therefore, a regular follow-up with a rigorous skin examination is essential in these patients. Noninvasive techniques such as dermoscopy or reflectance confocal microscopy are particularly useful diagnostic tools in these circumstances.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
LILACS
/
Coleciona SUS
Main subject:
Skin Neoplasms
/
Nevus, Epithelioid and Spindle Cell
Type of study:
Diagnostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
An. bras. dermatol
Year:
2020
Document type:
Article
Institution/Affiliation country:
Centro Hospitalar e Universitário de Lisboa Norte/PT