Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives
Braz. J. Pharm. Sci. (Online)
; 56: e18654, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1132041
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of a new series of 4-Hydroxycoumarin derivatives synthesized through Knovenegal condensation; they were characterized by using UV-Vis, FT-IR, NMR spectroscopies. The synthesized compounds were evaluated for antibacterial activity against Staphylococcus aureus and Salmonella typhimurium strains. The compounds (2), (3) and (8) showed favorable antibacterial activity with zone of inhibitions 26.5± 0.84, 26.0 ± 0.56 and 26.0 ± 0.26 against Staphylococcus aureus (Gram-positive) respectively. However, the compounds (5) and (9) were found more active with 19.5 ± 0.59 and 19.5 ± 0.32 zone of inhibitions against Salmonella typhimurium (Gram-negative). Whereas, in urease inhibition assay, none of the synthesized derivatives showed significant anti-urease activity; although, in carbonic anhydrase-II inhibition assay, the compound (2) and (6) showed enzyme inhibition activity with IC50 values 263±0.3 and 456±0.1, respectively.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
LILACS
Main subject:
Carbonic Anhydrases
/
Inhibitory Concentration 50
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Document type:
Article
Affiliation country:
China
/
Pakistan
/
Saudi Arabia
Institution/Affiliation country:
Bahauddin Zakariya University/PK
/
COMSATS University Islamabad/PK
/
King Saud University/SA
/
Matter Chinese Academy of Science/CN
/
Schanghai Jiao Tong University/CN