Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 42(5): 481-488, Sept.-Oct. 2020. tab
Article
in English
| LILACS
| ID: biblio-1132115
Responsible library:
BR1.1
ABSTRACT
Objectives:
To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder.Methods:
Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion).Results:
Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion.Conclusions:
Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Bipolar Disorder
/
Depressive Disorder, Major
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Humans
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2020
Document type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Harvard Longwood Psychiatry Residency Training Program/US
/
University of Cincinnati College of Medicine/US
/
University of Texas at Austin/US