Effect of CPP-ACP on remineralization of artificial caries-like lesion: an in situ study
Braz. oral res. (Online)
; 34: e061, 2020. tab, graf
Article
in English
| LILACS, BBO - Dentistry
| ID: biblio-1132676
Responsible library:
BR1.1
ABSTRACT
Abstract The purpose of this double-blind, randomized, crossover in situ study is to compare remineralization of preformed enamel lesions by casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) and fluoride dentifrice products. During each of four 10-day experimental legs, 10 participants wore intraoral removable palatal acrylic appliances with four human enamel slabs with preformed lesions. A 0.03-mL treatment paste was dripped extraorally onto the enamel blocks once a day for 3 min. The four randomly allocated treatments were as follows CO- Control silica dentifrice without fluoride; MP MI Paste; MPP MI Paste Plus and FD Fluoride dentifrice - 1100 ppm F as NaF). Knoop surface hardness (SH) test was performed in three stages (T0 - sound enamel, T1 - after preformed lesion, and T2 - after treatment) and the cross-sectional hardness (CSH) test was performed after treatment using a 50-gram Knoop load for 15 s. Knoop hardness number (KHN) was similar between treatments. %SHr was significantly higher in the MP, FD, and MPP when compared to CO group (Kruskal-Wallis and Mann-Whitney tests, p < 0.05). Harder enamel was found in MP (75 μm) and FD groups at 75 to 175 μm. Treatment with DF, MP, and MPP promoted an increase of 20.27%, 19.24%, and 14.71%, respectively, in Integral Hardness Change (ΔIHC) when compared to CO (p<0.05). Remineralizing agents (MP, MPP, and DF) were able to inhibit demineralization of human enamel subjected to high cariogenic challenge in situ. DF had the greatest preventive potential against the progression of carious lesions.
Full text:
Available
Collection:
International databases
Database:
BBO - Dentistry
/
LILACS
Main subject:
Tooth Remineralization
Type of study:
Controlled clinical trial
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. oral res. (Online)
Journal subject:
Dentistry
Year:
2020
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal Fluminense/BR