COVID-19 in solid organ transplantation patients: A systematic review
Clinics
; Clinics;75: e1983, 2020. tab, graf
Article
in En
| LILACS
| ID: biblio-1133389
Responsible library:
BR1.1
ABSTRACT
Coronavirus disease (COVID-19) rapidly progresses to severe acute respiratory syndrome. This review aimed at collating available data on COVID-19 infection in solid organ transplantation (SOT) patients. We performed a systematic review of SOT patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MEDLINE and PubMed databases were electronically searched and updated until April 20, 2020. The MeSH terms used were "COVID-19" AND "Transplant." Thirty-nine COVID-19 cases were reported among SOT patients. The median interval for developing SARS-CoV-2 infection was 4 years since transplantation, and the fatality rate was 25.64% (10/39). Sixteen cases were described in liver transplant (LT) patients, and the median interval since transplantation was 5 years. The fatality rate among LT patients was 37.5% (6/16), with death occurring more than 3 years after LT. The youngest patient who died was 59 years old; there were no deaths among children. Twenty-three cases were described in kidney transplant (KT) patients. The median interval since transplantation was 4 years, and the fatality rate was 17.4% (4/23). The youngest patient who died was 71 years old. Among all transplant patients, COVID-19 had the highest fatality rate in patients older than 60 years LT, 62.5% vs 12.5% (p=0.006); KT 44.44% vs 0 (p=0.039); and SOT, 52.94% vs 4.54% (p=0.001). This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299)
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Pneumonia, Viral
/
Kidney Transplantation
/
Liver Transplantation
/
Coronavirus Infections
/
Betacoronavirus
Type of study:
Systematic_reviews
Limits:
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2020
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil