Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;53: e20200372, 2020. graf
Article
in En
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136859
Responsible library:
BR1.1
ABSTRACT
Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
/
SES-SP
/
ColecionaSUS
Main subject:
RNA, Viral
/
Coronavirus Infections
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2020
Document type:
Article
Affiliation country:
China
Country of publication:
Brazil