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The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence
Aurilio, Rafaela Baroni; Marsili, Vivian Vidal; Malaquias, Thiago da Silva Santos; Kritski, Afrânio Lineu; SantAnna, Clemax Couto.
Affiliation
  • Aurilio, Rafaela Baroni; Universidade Federal do Rio de Janeiro. Instituto de Pediatria e Puericultura Martagão Gesteira. Rio de Janeiro. BR
  • Marsili, Vivian Vidal; Universidade Federal do Rio de Janeiro. Instituto de Pediatria e Puericultura Martagão Gesteira. Rio de Janeiro. BR
  • Malaquias, Thiago da Silva Santos; Universidade Federal do Rio de Janeiro. Instituto de Doenças do Tórax. Rio de Janeiro. BR
  • Kritski, Afrânio Lineu; Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Instituto de Doenças do Tórax. Rio de Janeiro. BR
  • SantAnna, Clemax Couto; Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Pediatria. Rio de Janeiro. BR
Rev. Soc. Bras. Med. Trop ; 53: e20200104, 2020. tab, graf
Article in English | Sec. Est. Saúde SP, Coleciona SUS, LILACS | ID: biblio-1136907
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Gene-Xpert MTB RIF (Xpert) is based on nucleic acid amplification by real-time polymerase chain reaction, which allows for the identification of Mycobacterium tuberculosis and rifampin resistance. We describe the use of Xpert for extrapulmonary tuberculosis (EPTB) in children and adolescents.

METHODS:

A case series of two reference centers in Rio de Janeiro from 2014-2019.

RESULTS:

The final diagnosis of EPTB was established in 11/36 (31%) patients, with five cases detectable by Xpert. For lymph node evaluation (9/11), diagnosis by Xpert occurred in 5/9 patients, all with caseous aspects.

CONCLUSIONS:

Xpert can facilitate the rapid diagnosis of lymph node tuberculosis.
Subject(s)

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Full text: Available Collection: National databases / Brazil Health context: Neglected Diseases Health problem: Neglected Diseases / Tuberculosis Database: LILACS / Sec. Est. Saúde SP / Coleciona SUS Main subject: Tuberculosis / Mycobacterium tuberculosis Type of study: Diagnostic study Limits: Adolescent / Child / Child, preschool / Humans / Infant Language: English Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Document type: Article Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR
Fulltext
Add to My VHL
Print
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Full text: Available Collection: National databases / Brazil Health context: Neglected Diseases Health problem: Neglected Diseases / Tuberculosis Database: LILACS / Sec. Est. Saúde SP / Coleciona SUS Main subject: Tuberculosis / Mycobacterium tuberculosis Type of study: Diagnostic study Limits: Adolescent / Child / Child, preschool / Humans / Infant Language: English Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Document type: Article Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR