Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy
Rev. Soc. Bras. Med. Trop
; 53: e20190404, 2020. tab, graf
Article
in En
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136910
Responsible library:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.METHODS:
Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007-2011 were subjected to drug susceptibility and IS6110-restriction fragment length polymorphism testing.RESULTS:
The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households.CONCLUSIONS:
Drug-resistant tuberculosis was relatively low and transmitted in households and the community.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
/
SES-SP
/
ColecionaSUS
Main subject:
Polymorphism, Restriction Fragment Length
/
Brazil
/
Prevalence
/
Cross-Sectional Studies
/
Tuberculosis, Multidrug-Resistant
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Directly Observed Therapy
/
Mycobacterium tuberculosis
Type of study:
Observational_studies
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Prevalence_studies
/
Risk_factors_studies
Limits:
Adolescent
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Adult
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Female
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Humans
/
Male
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2020
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil