Comparison between the effects of bretschneiders htk solution and cold blood cardioplegia on systemic endothelial functions in patients who undergo coronary artery bypass surgery: a prospective randomized and controlled trial
Rev. bras. cir. cardiovasc
; 35(5): 634-643, Sept.-Oct. 2020. tab, graf
Article
in English
| LILACS, Sec. Est. Saúde SP
| ID: biblio-1137349
Responsible library:
BR1.1
ABSTRACT
Abstract Objective:
To investigate the effects of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution and cold blood cardioplegia on systemic endothelial functions.Methods:
A total of 50 patients who underwent isolated coronary artery bypass surgery between March 2018 and May 2018 were randomly divided into two groups - group 1 (Bretschneider's HTK solution, n=25) and group 2 (cold blood cardioplegia, n=25). Data related to the indicators of endothelial dysfunction were recorded. Flow-mediated dilation was measured together with the assessment of the values of endothelin-1, von Willebrand factor, and asymmetric dimethylarginine to identify endothelial dysfunction. Then, the two groups were compared regarding these values.Results:
The most significant result of our study was that the endothelin-1 level was significantly higher in group 2 than in group 1 (P<0.001). The value of flow-mediated dilation was found to increase to a lesser degree on the postoperative days compared to the value at the day of admission in group 1 (P=0.002 and P=0.030, respectively).Conclusion:
Cardiopulmonary bypass leads to endothelial dysfunction. Our results revealed that Bretschneider's HTK solution causes less severe endothelial injury than cold blood cardioplegia.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
LILACS
/
Sec. Est. Saúde SP
Main subject:
Cardioplegic Solutions
/
Coronary Artery Bypass
/
Heart Arrest, Induced
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. bras. cir. cardiovasc
Year:
2020
Document type:
Article
Institution/Affiliation country:
Konya Training and Research Hospital/TR
/
Necmettin Erbakan University/TR