Glycolytic pathway candidate markers in the prognosis of oral squamous cell carcinoma: a systematic review with meta-analysis
Braz. j. med. biol. res
; 54(3): e10504, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1153517
Responsible library:
BR1.1
ABSTRACT
Molecular changes that affect mitochondrial glycolysis have been associated with the maintenance of tumor cells. Some metabolic factors have already been described as predictors of disease severity and outcomes. This systematic review was conducted to answer the question Is the glycolytic pathway correlated with the prognosis of oral squamous cell carcinoma (OSCC)? A search strategy was developed to retrieve studies in English from PubMed, Scopus, and ISI Web of Science using keywords related to squamous cell carcinoma, survival, and glycolytic pathway, with no restriction of publication date. The search retrieved 1273 publications. After the titles and abstracts were analyzed, 27 studies met inclusion criteria. Studies were divided into groups according to two subtopics, glycolytic pathways and diagnosis, which describe the glycolytic profile of OSCC tumors. Several components of tumor energy metabolism found in this review are important predictors of survival of patients with OSCC.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Mouth Neoplasms
/
Squamous Cell Carcinoma of Head and Neck
/
Glycolysis
Type of study:
Prognostic study
/
Systematic review
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2021
Document type:
Article
Affiliation country:
Brazil
/
Colombia
Institution/Affiliation country:
Universidad De La Costa/CO
/
Universidade Federal do Rio Grande do Sul/BR