Anulacion de la autorregulacion de flujo sanguineo cortical renal inducida por el ClNa no atribuible al aumento de osmolaridad / [Avoidance of renal cortical blood flow autoregulation induced by NaCl not attributable to plasma asmolarity changes (author’s transl)]

ABSTRACT

Experiments were conducted on rats to investigate the acute effects on renal cortical blood flow and cortical autoregulation caused by intravenous administration of hypertonic solutions of sodium chloride or glucose. Local blood flow was measured in renal cortex (at 1 mm below cortical surface) by means of the hydrogen clearance method in urethanized rats. Recording of blood pressure from femoral artery was performed. In control group, renal cortical vascular resistance (R.C.V.R.)--arterial pressure relationships demonstrated typical autoregulation. An increase in plasma osmolarity of approximately 5.90