Efecto de distintos esquemas de administración de ciclofosfamida en la mortalidad del ratón adulto infectado con virus Junín / [Effect of various schedules of cyclophosphamide administration on the mortality of the adult mouse infected with Junín virus]
Rev. argent. microbiol
; 16(4): 229-32, 1984.
Article
in Spanish
|
LILACS-Express
| LILACS, BINACIS
| ID: biblio-1171519
Responsible library:
AR32.1
Localization: [{"text": "AR32.1"}]
ABSTRACT
The object of this paper was to determine the influence of cyclophosphamide immunosuppression on the mortality of 40-45 day old Balb/c mice infected intracerebrally with a pathogenic strain of Junin virus, using different administration schedules. Up to 200 mg/kg of cyclophosphamide were not toxic. Results show that, unlike in other experimental models, three or four 50 mg/kg cyclophosphamide doses given both before and after viral infection were required to break-down resistance to Junin virus (90-96.5
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Collection:
International databases
Database:
BINACIS
/
LILACS
Language:
Spanish
Journal:
Rev. argent. microbiol
Journal subject:
Microbiology
Year:
1984
Document type:
Article